Transcranial magnetic stimulation and silent period in spasmodic torticollis

Stefano Amadio, Marcela Panizza, Fabrizio Pisano, Luca Maderna, Cinzia Miscio, Jan Nilsson, Maria Antonietta Volonté, Giancarlo Comi, Giuseppe Galardi

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Our objective was to study the corticobulbar projections to neck muscles in cervical dystonia. Design: We compared both the motor evoked potentials and the electromyographic silent period after transcranial magnetic stimulation from sternocleidomastoid and trapezius muscles in a group of 13 patients with spasmodic torticollis with those of 20 healthy volunteers. Results: With the target muscle at rest, no changes of motor threshold, motor evoked potentials latency, and amplitude were observed in dystonic patients. With facilitation, the mean amplitude of the motor evoked potentials was increased in patients compared with controls, the significant difference being for the trapezius muscle, whereas the latency did not differ between groups. The cortical silent period was significantly shorter in dystonic patients than in healthy subjects in both muscles. The duration of the cortical silent period recorded from the sternocleidomastoid muscle showed a positive correlation with the degree of neurologic disability assessed by Tsui's scale. No abnormalities of both nerve conduction velocity and peripheral silent period by stimulation of accessory nerve were found. Conclusions: These results indicate an impairment of the mechanisms of inhibitory motor control in patients with spasmodic torticollis, which could be the result of a decrease of the basal ganglia inhibitory output over the motor cortex.

Original languageEnglish
Pages (from-to)361-368
Number of pages8
JournalAmerican Journal of Physical Medicine and Rehabilitation
Volume79
Issue number4
DOIs
Publication statusPublished - Jul 2000

Keywords

  • Cortical Silent Period
  • Motor Evoked Potentials
  • Movement Disorders
  • Spasmodic Torticollis
  • Transcranial Magnetic Stimulation

ASJC Scopus subject areas

  • Rehabilitation
  • Health Professions(all)
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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