Transcranial magnetic stimulation-evoked EEG/cortical potentials in physiological and pathological aging

Silvia Casarotto, Sara Määttä, Sanna Kaisa Herukka, Andrea Pigorini, Martino Napolitani, Olivia Gosseries, Eini Niskanen, Mervi Könönen, Esa Mervaala, Mario Rosanova, Hilkka Soininen, Marcello Massimini

Research output: Contribution to journalArticlepeer-review

Abstract

The frontal cortex undergoes macrostructural and microstructural changes across the lifespan. These changes can be entirely physiological, such as the ones occurring in elderly individuals who are cognitively intact, or pathological, such as the ones occurring in patients with Alzheimer's disease. Here, we use simultaneous electroencephalography (EEG) and transcranial magnetic stimulation (TMS) to study how the excitability of the frontal cortex changes during healthy and pathological aging. Hence, we compared the TMS-evoked EEG potentials collected in healthy elderly individuals with the ones collected in healthy young individuals, and in patients with Alzheimer's disease. We have shown that the EEG response to TMS of the left superior frontal cortex is not affected by physiological aging but is markedly altered by cognitive impairment.

Original languageEnglish
Pages (from-to)592-597
Number of pages6
JournalNeuroReport
Volume22
Issue number12
DOIs
Publication statusPublished - Aug 24 2011

Keywords

  • aging
  • Alzheimer
  • cortical excitability
  • electroencephalography
  • transcranial magnetic stimulation

ASJC Scopus subject areas

  • Neuroscience(all)

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