TY - JOUR
T1 - Transcranial magnetic stimulation-evoked EEG/cortical potentials in physiological and pathological aging
AU - Casarotto, Silvia
AU - Määttä, Sara
AU - Herukka, Sanna Kaisa
AU - Pigorini, Andrea
AU - Napolitani, Martino
AU - Gosseries, Olivia
AU - Niskanen, Eini
AU - Könönen, Mervi
AU - Mervaala, Esa
AU - Rosanova, Mario
AU - Soininen, Hilkka
AU - Massimini, Marcello
PY - 2011/8/24
Y1 - 2011/8/24
N2 - The frontal cortex undergoes macrostructural and microstructural changes across the lifespan. These changes can be entirely physiological, such as the ones occurring in elderly individuals who are cognitively intact, or pathological, such as the ones occurring in patients with Alzheimer's disease. Here, we use simultaneous electroencephalography (EEG) and transcranial magnetic stimulation (TMS) to study how the excitability of the frontal cortex changes during healthy and pathological aging. Hence, we compared the TMS-evoked EEG potentials collected in healthy elderly individuals with the ones collected in healthy young individuals, and in patients with Alzheimer's disease. We have shown that the EEG response to TMS of the left superior frontal cortex is not affected by physiological aging but is markedly altered by cognitive impairment.
AB - The frontal cortex undergoes macrostructural and microstructural changes across the lifespan. These changes can be entirely physiological, such as the ones occurring in elderly individuals who are cognitively intact, or pathological, such as the ones occurring in patients with Alzheimer's disease. Here, we use simultaneous electroencephalography (EEG) and transcranial magnetic stimulation (TMS) to study how the excitability of the frontal cortex changes during healthy and pathological aging. Hence, we compared the TMS-evoked EEG potentials collected in healthy elderly individuals with the ones collected in healthy young individuals, and in patients with Alzheimer's disease. We have shown that the EEG response to TMS of the left superior frontal cortex is not affected by physiological aging but is markedly altered by cognitive impairment.
KW - aging
KW - Alzheimer
KW - cortical excitability
KW - electroencephalography
KW - transcranial magnetic stimulation
UR - http://www.scopus.com/inward/record.url?scp=80051508020&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80051508020&partnerID=8YFLogxK
U2 - 10.1097/WNR.0b013e328349433a
DO - 10.1097/WNR.0b013e328349433a
M3 - Article
C2 - 21753711
AN - SCOPUS:80051508020
VL - 22
SP - 592
EP - 597
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 12
ER -