Transcranial magnetic stimulation-evoked EEG/cortical potentials in physiological and pathological aging

Silvia Casarotto; Sara Määttä; Sanna Kaisa Herukka; Andrea Pigorini; Martino Napolitani; Olivia Gosseries; Eini Niskanen; Mervi Könönen; Esa Mervaala; Mario Rosanova; Hilkka Soininen; Marcello Massimini

doi:10.1097/WNR.0b013e328349433a

Transcranial magnetic stimulation-evoked EEG/cortical potentials in physiological and pathological aging

Silvia Casarotto, Sara Määttä, Sanna Kaisa Herukka, Andrea Pigorini, Martino Napolitani, Olivia Gosseries, Eini Niskanen, Mervi Könönen, Esa Mervaala, Mario Rosanova, Hilkka Soininen, Marcello Massimini

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

The frontal cortex undergoes macrostructural and microstructural changes across the lifespan. These changes can be entirely physiological, such as the ones occurring in elderly individuals who are cognitively intact, or pathological, such as the ones occurring in patients with Alzheimer's disease. Here, we use simultaneous electroencephalography (EEG) and transcranial magnetic stimulation (TMS) to study how the excitability of the frontal cortex changes during healthy and pathological aging. Hence, we compared the TMS-evoked EEG potentials collected in healthy elderly individuals with the ones collected in healthy young individuals, and in patients with Alzheimer's disease. We have shown that the EEG response to TMS of the left superior frontal cortex is not affected by physiological aging but is markedly altered by cognitive impairment.

Original language	English
Pages (from-to)	592-597
Number of pages	6
Journal	NeuroReport
Volume	22
Issue number	12
DOIs	https://doi.org/10.1097/WNR.0b013e328349433a
Publication status	Published - Aug 24 2011

Keywords

aging
Alzheimer
cortical excitability
electroencephalography
transcranial magnetic stimulation

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1097/WNR.0b013e328349433a

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Transcranial magnetic stimulation-evoked EEG/cortical potentials in physiological and pathological aging. / Casarotto, Silvia; Määttä, Sara; Herukka, Sanna Kaisa; Pigorini, Andrea; Napolitani, Martino; Gosseries, Olivia; Niskanen, Eini; Könönen, Mervi; Mervaala, Esa; Rosanova, Mario; Soininen, Hilkka; Massimini, Marcello.

In: NeuroReport, Vol. 22, No. 12, 24.08.2011, p. 592-597.

Research output: Contribution to journal › Article › peer-review

Casarotto, Silvia ; Määttä, Sara ; Herukka, Sanna Kaisa ; Pigorini, Andrea ; Napolitani, Martino ; Gosseries, Olivia ; Niskanen, Eini ; Könönen, Mervi ; Mervaala, Esa ; Rosanova, Mario ; Soininen, Hilkka ; Massimini, Marcello. / Transcranial magnetic stimulation-evoked EEG/cortical potentials in physiological and pathological aging. In: NeuroReport. 2011 ; Vol. 22, No. 12. pp. 592-597.

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