Transcranial magnetic stimulation in Alzheimer disease: Motor cortex excitability and cognitive severity

Giovanna Alagona, Rita Bella, Raffaele Ferri, Anna Carnemolla, Alessandra Pappalardo, Erminio Costanzo, Giovanni Pennisi

Research output: Contribution to journalArticlepeer-review

Abstract

To study the possible changes of cortical excitability in the Alzheimer disease (AD) by transcranial magnetic stimulation (TMS) and to evaluate their eventual correlation with its stage twenty-one AD patients and 18 normal controls underwent TMS. Motor threshold, amplitudes of motor evoked potentials (MEPs), central motor conduction time (CMCT) and silent period (SP) were considered. The motor threshold in AD patients was lower than in normal subjects with a significant correlation between the stage of cognitive severity. The amplitude of MEPs was increased and the SP duration was reduced in AD patients. No significant differences were obtained for CMCT. These findings could suggest a correlation between increased motor cortical excitability and cognitive severity. Moreover, the increased cortical excitability could represent a key to understand the mechanism of AD and may have implication for novel treatment strategies.

Original languageEnglish
Pages (from-to)57-60
Number of pages4
JournalNeuroscience Letters
Volume314
Issue number1-2
DOIs
Publication statusPublished - Nov 13 2001

Keywords

  • Alzheimer disease
  • Motor cortex excitability
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Neuroscience(all)

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