Transcranial Magnetic Stimulation Over the Human Medial Posterior Parietal Cortex Disrupts Depth Encoding During Reach Planning

Rossella Breveglieri, Annalisa Bosco, Sara Borgomaneri, Alessia Tessari, Claudio Galletti, Alessio Avenanti, Patrizia Fattori

Research output: Contribution to journalArticlepeer-review

Abstract

Accumulating evidence supports the view that the medial part of the posterior parietal cortex (mPPC) is involved in the planning of reaching, but while plenty of studies investigated reaching performed toward different directions, only a few studied different depths. Here, we investigated the causal role of mPPC (putatively, human area V6A-hV6A) in encoding depth and direction of reaching. Specifically, we applied single-pulse transcranial magnetic stimulation (TMS) over the left hV6A at different time points while 15 participants were planning immediate, visually guided reaching by using different eye-hand configurations. We found that TMS delivered over hV6A 200 ms after the Go signal affected the encoding of the depth of reaching by decreasing the accuracy of movements toward targets located farther with respect to the gazed position, but only when they were also far from the body. The effectiveness of both retinotopic (farther with respect to the gaze) and spatial position (far from the body) is in agreement with the presence in the monkey V6A of neurons employing either retinotopic, spatial, or mixed reference frames during reach plan. This work provides the first causal evidence of the critical role of hV6A in the planning of visually guided reaching movements in depth.

Original languageEnglish
Pages (from-to)267-280
Number of pages14
JournalCerebral cortex (New York, N.Y. : 1991)
Volume31
Issue number1
DOIs
Publication statusPublished - Sep 2020

Keywords

  • eye-hand configuration
  • human V6A
  • reach plan
  • reaching in-depth
  • transcranial magnetic stimulation

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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