Transcribed-ultra conserved region expression is associated with outcome in high-risk neuroblastoma

Paola Scaruffi, Sara Stigliani, Stefano Moretti, Simona Coco, Carla De Vecchi, Francesca Valdora, Alberto Garaventa, Stefano Bonassi, Gian P. Tonini

Research output: Contribution to journalArticle

Abstract

Background: Neuroblastoma is the most common, pediatric, extra-cranial, malignant solid tumor. Despite multimodal therapeutic protocols, outcome for children with a high-risk clinical phenotype remains poor, with long-term survival still less than 40%. Hereby, we evaluated the potential of non-coding RNA expression to predict outcome in high-risk, stage 4 neuroblastoma.Methods: We analyzed expression of 481 Ultra Conserved Regions (UCRs) by reverse transcription-quantitative real-time PCR and of 723 microRNAs by microarrays in 34 high-risk, stage 4 neuroblastoma patients.Results: First, the comparison of 8 short- versus 12 long-term survivors showed that 54 UCRs were significantly (P <0.0491) over-expressed in the former group. For 48 Ultra Conserved Region (UCRs) the expression levels above the cut-off values defined by ROC curves were strongly associated with good-outcome (OS: 0.0001

Original languageEnglish
Article number441
JournalBMC Cancer
Volume9
DOIs
Publication statusPublished - Dec 15 2009

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Genetics

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    Scaruffi, P., Stigliani, S., Moretti, S., Coco, S., De Vecchi, C., Valdora, F., Garaventa, A., Bonassi, S., & Tonini, G. P. (2009). Transcribed-ultra conserved region expression is associated with outcome in high-risk neuroblastoma. BMC Cancer, 9, [441]. https://doi.org/10.1186/1471-2407-9-441