Transcription factor TBX1 overexpression induces downregulation of proteins involved in retinoic acid metabolism: A comparative proteomic analysis

Marianna Caterino, Margherita Ruoppolo, Gabriella Fulcoli, Tuong Huynth, Stefania Orrù, Antonio Baldini, Francesco Salvatore

Research output: Contribution to journalArticlepeer-review

Abstract

TBX1 haploinsufficiency is considered a major contributor to the del22q11.2/DiGeorge syndrome (DGS) phenotype. We have used proteomic tools to look at all the major proteins involved in the TBXI-mediated pathways in an attempt to better understand the molecular interactions instrumental to its cellular functions. We found more than 90 proteins that could be targeted by TBX1 through different mechanisms. The most interesting observation is that overexpression of TBX1 results in down-regulation of two proteins involved in retinoic acid metabolism.

Original languageEnglish
Pages (from-to)1515-1526
Number of pages12
JournalJournal of Proteome Research
Volume8
Issue number3
DOIs
Publication statusPublished - Mar 6 2009

Keywords

  • DIGE
  • DiGeorge syndrome
  • Proteomics
  • Retinoic acid
  • T-box containing transcription factor

ASJC Scopus subject areas

  • Biochemistry
  • Chemistry(all)

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