Transcription factor TBX1 overexpression induces downregulation of proteins involved in retinoic acid metabolism: A comparative proteomic analysis

Marianna Caterino; Margherita Ruoppolo; Gabriella Fulcoli; Tuong Huynth; Stefania Orrù; Antonio Baldini; Francesco Salvatore

doi:10.1021/pr800870d

Transcription factor TBX1 overexpression induces downregulation of proteins involved in retinoic acid metabolism: A comparative proteomic analysis

Marianna Caterino, Margherita Ruoppolo, Gabriella Fulcoli, Tuong Huynth, Stefania Orrù, Antonio Baldini, Francesco Salvatore

Research output: Contribution to journal › Article › peer-review

Abstract

TBX1 haploinsufficiency is considered a major contributor to the del22q11.2/DiGeorge syndrome (DGS) phenotype. We have used proteomic tools to look at all the major proteins involved in the TBXI-mediated pathways in an attempt to better understand the molecular interactions instrumental to its cellular functions. We found more than 90 proteins that could be targeted by TBX1 through different mechanisms. The most interesting observation is that overexpression of TBX1 results in down-regulation of two proteins involved in retinoic acid metabolism.

Original language	English
Pages (from-to)	1515-1526
Number of pages	12
Journal	Journal of Proteome Research
Volume	8
Issue number	3
DOIs	https://doi.org/10.1021/pr800870d
Publication status	Published - Mar 6 2009

Keywords

DIGE
DiGeorge syndrome
Proteomics
Retinoic acid
T-box containing transcription factor

ASJC Scopus subject areas

Biochemistry
Chemistry(all)

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10.1021/pr800870d

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Transcription factor TBX1 overexpression induces downregulation of proteins involved in retinoic acid metabolism : A comparative proteomic analysis. / Caterino, Marianna; Ruoppolo, Margherita; Fulcoli, Gabriella; Huynth, Tuong; Orrù, Stefania; Baldini, Antonio; Salvatore, Francesco.

In: Journal of Proteome Research, Vol. 8, No. 3, 06.03.2009, p. 1515-1526.

Research output: Contribution to journal › Article › peer-review

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abstract = "TBX1 haploinsufficiency is considered a major contributor to the del22q11.2/DiGeorge syndrome (DGS) phenotype. We have used proteomic tools to look at all the major proteins involved in the TBXI-mediated pathways in an attempt to better understand the molecular interactions instrumental to its cellular functions. We found more than 90 proteins that could be targeted by TBX1 through different mechanisms. The most interesting observation is that overexpression of TBX1 results in down-regulation of two proteins involved in retinoic acid metabolism.",

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AU - Baldini, Antonio

AU - Salvatore, Francesco

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