Transcription of unrearranged T cell receptor δ genes in CD3- major histocompatibility complex-unrestricted cytotoxic cells

R. Biassoni, S. Ferrini, R. P. Sekaly, E. O. Long

Research output: Contribution to journalArticle

Abstract

Transcription of the T cell receptor (TcR) δ gene was detected in clones and in enriched populations of CD3- major histocompatibility complex-unrestricted cytotoxic cells. The transcripts were derived, at least in part, from unrearranged TcR δ genes, as shown by hybridization to a synthetic oligonucleotide probe corresponding to germ-line sequences just upstream of J(δ)1. Transcripts from unrearranged TcR δ genes are similar in size to those from productively rearranged genes. The fact that the bulk of δ transcripts was derived from unrearranged genes was supported by the observation that TcR δ gene rearrangements were not detected in DNA isolated from an enriched CD3- cytotoxic cell population. Transcription of the TcR δ gene in CD3- cytotoxic cells is consistent with the notion that these cells belong to a T cell lineage.

Original languageEnglish
Pages (from-to)1973-1976
Number of pages4
JournalEuropean Journal of Immunology
Volume19
Issue number10
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Immunology

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