Transcriptional and epigenetic phenomena in peripheral blood cells of monozygotic twins discordant for alzheimer's disease, a case report

Claudio D'Addario, Sussy Bastias Candia, Beatrice Arosio, Martina Di Bartolomeo, Carlo Abbate, Alessandra Casè, Sanzio Candeletti, Patrizia Romualdi, Sarah Damanti, Mauro Maccarrone, Luigi Bergamaschini, Daniela Mari

Research output: Contribution to journalArticle

Abstract

Target genes in Alzheimer's disease (AD) have been identified. In monozygotic twins discordant for AD we analysed the expression of selected genes, and their possible regulation by epigenetic mechanisms in peripheral blood mononuclear cells, possibly useful to discover biomarkers. Amyloid precursor protein, sirtuin 1 and peptidyl prolyl isomerase 1 gene expressions were highly up-regulated in the AD twin versus the healthy one. Consistently with sirtuin 1 role in controlling acetylation status, we observed a substantial reduction of the acetylation on histone 3 lysine 9, associated with gene transcription in the AD twin. Noteworthy in the AD twin we also observed an increased gene expression in two histone deacetylases (HDACs) isoforms: HDAC2 and HDAC9. A general DNA hypomethylation of all gene promoters studied was also observed in both twins. Our results unravel transcriptional and epigenetic differences potentially helpful to better understand environmental factors and phenotypic differences in monozygotic twins.

Original languageEnglish
Pages (from-to)211-216
Number of pages6
JournalJournal of the Neurological Sciences
Volume372
DOIs
Publication statusE-pub ahead of print - Nov 24 2016

Keywords

  • Alzheimer's disease
  • Epigenetic mechanisms
  • Gene expression
  • Monozygotic twins
  • Peripheral blood mononuclear cells

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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  • Cite this

    D'Addario, C., Candia, S. B., Arosio, B., Di Bartolomeo, M., Abbate, C., Casè, A., Candeletti, S., Romualdi, P., Damanti, S., Maccarrone, M., Bergamaschini, L., & Mari, D. (2016). Transcriptional and epigenetic phenomena in peripheral blood cells of monozygotic twins discordant for alzheimer's disease, a case report. Journal of the Neurological Sciences, 372, 211-216. https://doi.org/10.1016/j.jns.2016.11.052