Transcriptional and epigenetic regulation of ncx1 and ncx3 in the brain

Luigi Formisano, Natascia Guida, Luigi Mascolo, Angelo Serani, Giusy Laudati, Vincenzo Pizzorusso, Lucio Annunziato

Research output: Contribution to journalArticlepeer-review

Abstract

Sodium-calcium exchanger (NCX) 1 and 3, have been demonstrated to play a relevant role in controlling the intracellular homeostasis of sodium and calcium ions in physiological and patho-physiological conditions. While NCX1 and NCX3 knocking-down have been both implicated in brain ischemia, several aspects of the epigenetic regulation of these two antiporters transcription were not yet well characterized. In response to stroke, NCX1 and NCX3 transcriptional regulation occurs from specific promoter sequences. Several evidences have shown that the expression of NCX1 and NCX3 can be determined by epigenetic modifications, consisting in changes of the histone acetylation levels on their promoter sequences. An interesting issue is that histone modifications at the NCX1 and NCX3 promoters could be linked to neurodegeneration occurring after stroke. Therefore, identifying the epigenetic regulation at the NCX1 and NCX3 promoters could permit to identify new molecular targets that can open new strategies for stroke treatment. The current review reassumes the recent knowledge of histone modifications of NCX1 and NCX3 genes in brain in physiological and patho-physiological conditions.

Original languageEnglish
Article number102194
JournalCell Calcium
Volume87
DOIs
Publication statusPublished - May 2020

Keywords

  • Cerebral ischemia
  • Epigenetic
  • Neurodegeneration

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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