TY - JOUR
T1 - Transcriptional control of skin reepithelialization
AU - Bellavia, Gabriella
AU - Fasanaro, Pasquale
AU - Melchionna, Roberta
AU - Capogrossi, Maurizio C.
AU - Napolitano, Monica
PY - 2014/1
Y1 - 2014/1
N2 - The wound healing process is characterized by a series of overlapping phases, such as coagulation, inflammation, reepithelialization/granulation tissue generation and remodeling.It is important to obtain a deeper insight into the cutaneous wound repair mechanisms, in order to develop novel pharmacological tools for the treatment of chronic non-healing ulcers which are a frequent and high morbidity complication of diabetes, ischaemia, venous insufficiency, and other local or systemic factors. Several transcription factors, many of which belong to gene families, are known to play a role in cutaneous wound repair through the orchestration of cellular responses which promote the reconstitution of skin integrity.The aim of this review is to provide an updated analysis of the transcription factor role in the reepithelialization process, in the context of skin wound repair.
AB - The wound healing process is characterized by a series of overlapping phases, such as coagulation, inflammation, reepithelialization/granulation tissue generation and remodeling.It is important to obtain a deeper insight into the cutaneous wound repair mechanisms, in order to develop novel pharmacological tools for the treatment of chronic non-healing ulcers which are a frequent and high morbidity complication of diabetes, ischaemia, venous insufficiency, and other local or systemic factors. Several transcription factors, many of which belong to gene families, are known to play a role in cutaneous wound repair through the orchestration of cellular responses which promote the reconstitution of skin integrity.The aim of this review is to provide an updated analysis of the transcription factor role in the reepithelialization process, in the context of skin wound repair.
KW - Skin
KW - Transcription factor
KW - Wound healing
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U2 - 10.1016/j.jdermsci.2013.08.007
DO - 10.1016/j.jdermsci.2013.08.007
M3 - Article
C2 - 24012494
AN - SCOPUS:84890127742
VL - 73
SP - 3
EP - 9
JO - Journal of Dermatological Science
JF - Journal of Dermatological Science
SN - 0923-1811
IS - 1
ER -