Transcriptional derepression as a cause of genetic diseases

Davide Gabellini, Rossella Tupler, Michael R. Green

Research output: Contribution to journalArticle

Abstract

Transcription of DNA into mRNA is a highly regulated process directed by a complex molecular machine comprising more than 100 proteins. Regulation of transcription occurs by both positive (transcriptional activation) and negative (transcriptional repression) mechanisms. Recently, inappropriate transcriptional derepression has been found as the underlying basis of several human genetic diseases. The putative target genes, whose inappropriate expression is thought to cause disease, have remained elusive but are being searched for intensively.

Original languageEnglish
Pages (from-to)239-245
Number of pages7
JournalCurrent Opinion in Genetics and Development
Volume13
Issue number3
DOIs
Publication statusPublished - Jun 2003

Fingerprint

Inborn Genetic Diseases
Medical Genetics
Transcriptional Activation
Messenger RNA
DNA
Genes
Proteins

ASJC Scopus subject areas

  • Genetics

Cite this

Transcriptional derepression as a cause of genetic diseases. / Gabellini, Davide; Tupler, Rossella; Green, Michael R.

In: Current Opinion in Genetics and Development, Vol. 13, No. 3, 06.2003, p. 239-245.

Research output: Contribution to journalArticle

Gabellini, Davide ; Tupler, Rossella ; Green, Michael R. / Transcriptional derepression as a cause of genetic diseases. In: Current Opinion in Genetics and Development. 2003 ; Vol. 13, No. 3. pp. 239-245.
@article{ad5440a8f86b4dc181f50280cb40cbf8,
title = "Transcriptional derepression as a cause of genetic diseases",
abstract = "Transcription of DNA into mRNA is a highly regulated process directed by a complex molecular machine comprising more than 100 proteins. Regulation of transcription occurs by both positive (transcriptional activation) and negative (transcriptional repression) mechanisms. Recently, inappropriate transcriptional derepression has been found as the underlying basis of several human genetic diseases. The putative target genes, whose inappropriate expression is thought to cause disease, have remained elusive but are being searched for intensively.",
author = "Davide Gabellini and Rossella Tupler and Green, {Michael R.}",
year = "2003",
month = "6",
doi = "10.1016/S0959-437X(03)00050-9",
language = "English",
volume = "13",
pages = "239--245",
journal = "Current Opinion in Genetics and Development",
issn = "0959-437X",
publisher = "Elsevier Limited",
number = "3",

}

TY - JOUR

T1 - Transcriptional derepression as a cause of genetic diseases

AU - Gabellini, Davide

AU - Tupler, Rossella

AU - Green, Michael R.

PY - 2003/6

Y1 - 2003/6

N2 - Transcription of DNA into mRNA is a highly regulated process directed by a complex molecular machine comprising more than 100 proteins. Regulation of transcription occurs by both positive (transcriptional activation) and negative (transcriptional repression) mechanisms. Recently, inappropriate transcriptional derepression has been found as the underlying basis of several human genetic diseases. The putative target genes, whose inappropriate expression is thought to cause disease, have remained elusive but are being searched for intensively.

AB - Transcription of DNA into mRNA is a highly regulated process directed by a complex molecular machine comprising more than 100 proteins. Regulation of transcription occurs by both positive (transcriptional activation) and negative (transcriptional repression) mechanisms. Recently, inappropriate transcriptional derepression has been found as the underlying basis of several human genetic diseases. The putative target genes, whose inappropriate expression is thought to cause disease, have remained elusive but are being searched for intensively.

UR - http://www.scopus.com/inward/record.url?scp=0038350652&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038350652&partnerID=8YFLogxK

U2 - 10.1016/S0959-437X(03)00050-9

DO - 10.1016/S0959-437X(03)00050-9

M3 - Article

C2 - 12787785

AN - SCOPUS:0038350652

VL - 13

SP - 239

EP - 245

JO - Current Opinion in Genetics and Development

JF - Current Opinion in Genetics and Development

SN - 0959-437X

IS - 3

ER -