Transcriptional derepression as a cause of genetic diseases

Davide Gabellini, Rossella Tupler, Michael R. Green

Research output: Contribution to journalArticlepeer-review

Abstract

Transcription of DNA into mRNA is a highly regulated process directed by a complex molecular machine comprising more than 100 proteins. Regulation of transcription occurs by both positive (transcriptional activation) and negative (transcriptional repression) mechanisms. Recently, inappropriate transcriptional derepression has been found as the underlying basis of several human genetic diseases. The putative target genes, whose inappropriate expression is thought to cause disease, have remained elusive but are being searched for intensively.

Original languageEnglish
Pages (from-to)239-245
Number of pages7
JournalCurrent Opinion in Genetics and Development
Volume13
Issue number3
DOIs
Publication statusPublished - Jun 2003

ASJC Scopus subject areas

  • Genetics

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