Transcriptional integration of mitogenic and mechanical signals by Myc and YAP

Ottavio Croci, Serena De Fazio, Francesca Biagioni, Elisa Donato, Marieta Caganova, Laura Curti, Mirko Doni, Silvia Sberna, Deborah Aldeghi, Chiara Biancotto, Alessandro Verrecchia, Daniela Olivero, Bruno Amati, Stefano Campaner

Research output: Contribution to journalArticlepeer-review

Abstract

Mammalian cells must integrate environmental cues to determine coherent physiological responses. The transcription factors Myc and YAP-TEAD act downstream from mitogenic signals, with the latter responding also to mechanical cues. Here, we show that these factors coordinately regulate genes required for cell proliferation. Activation of Myc led to extensive association with its genomic targets, most of which were prebound by TEAD. At these loci, recruitment of YAP was Myc-dependent and led to full transcriptional activation. This cooperation was critical for cell cycle entry, organ growth, and tumorigenesis. Thus, Myc and YAP-TEAD integrate mitogenic and mechanical cues at the transcriptional level to provide multifactorial control of cell proliferation.

Original languageEnglish
Pages (from-to)2017-2022
Number of pages6
JournalGenes and Development
Volume31
Issue number20
DOIs
Publication statusPublished - Oct 15 2017

Keywords

  • Hippo signaling
  • Myc
  • TEAD
  • Transcription
  • YAP

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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