Transcriptional organization of a 450-kb region of the human X chromosome in Xq28

S. Bione, F. Tamanini, E. Maestrini, C. Tribioli, A. Poustka, G. Torri, S. Rivella, D. Toniolo

Research output: Contribution to journalArticle

Abstract

In this paper, we report the transcriptional organization of a 450-kb gene cluster in Xq28, flanked by the glucose-6-phosphate dehydrogenase and the color vision genes. CpG islands previously identified and mapped to distal Xq28 have helped in construction of a continuous contig of cosmids and in identification of cDNAs corresponding to eight transcripts. Thirteen to 16 small genes with CpG islands are clustered in a region of 250-300 kb. Many are highly expressed in muscle or brain and may be the genes responsible for muscle or neurological disorders mapped to distal Xq28. Our analysis indicates that, in this region of the genome, genes not related in sequence are organized in transcriptional domains of 100 kb and that this organization may be important for establishing and regulating gene expression in relation to tissue distribution and X chromosome inactivation.

Original languageEnglish
Pages (from-to)10977-10981
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume90
Issue number23
Publication statusPublished - Dec 1 1993

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Keywords

  • cDNA
  • CpG islands
  • Human genes
  • Human genome

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

Bione, S., Tamanini, F., Maestrini, E., Tribioli, C., Poustka, A., Torri, G., Rivella, S., & Toniolo, D. (1993). Transcriptional organization of a 450-kb region of the human X chromosome in Xq28. Proceedings of the National Academy of Sciences of the United States of America, 90(23), 10977-10981.