Transcriptional profile of denervated vastus lateralis muscle derived from a patient 8 months after spinal cord injury: A case report

R. Mancinelli, H. Kern, S. Fulle, U. Carraro, S. Zampieri, R. L A Rovere, G. Fanò, T. Pietrangelo

Research output: Contribution to journalArticle

Abstract

A lack of motor neurons abolishes both neurotrophic factor secretion and contractile activity in muscle, which impairs mass, contractile properties, and fibre-type characteristics of the muscle. However, the molecular pathways that can be stimulated or repressed in the scenario of spinal cord injury remain unknown. We investigated for the first time the transcriptional profile of a young male patient 8 months after spinal cord injury. Adaptive metabolic changes of complete denervated skeletal muscle were revealed. In particular, the main molecular pathways involved include metabolic and proteolitic pathways, mitochondrial and synaptic function, calcium homeostasis, sarcomere and anchorage structures. Our data depict the molecular signalling still present in complete denervated skeletal muscle fibres a few months after spinal cord injury. These data could be of interest also to design a specific therapeutic approach aimed at the electrical-stimulation of severe atrophied skeletal muscle.

Original languageEnglish
Pages (from-to)749-759
Number of pages11
JournalInternational Journal of Immunopathology and Pharmacology
Volume24
Issue number3
Publication statusPublished - Jul 2011

Fingerprint

Quadriceps Muscle
Spinal Cord Injuries
Muscles
Skeletal Muscle
Sarcomeres
Skeletal Muscle Fibers
Nerve Growth Factors
Motor Neurons
Metabolic Networks and Pathways
Electric Stimulation
Homeostasis
Calcium
Therapeutics

Keywords

  • Atrophy
  • Spinal cord injury
  • Transcriptoma

ASJC Scopus subject areas

  • Pharmacology
  • Immunology
  • Immunology and Allergy

Cite this

Mancinelli, R., Kern, H., Fulle, S., Carraro, U., Zampieri, S., Rovere, R. L. A., ... Pietrangelo, T. (2011). Transcriptional profile of denervated vastus lateralis muscle derived from a patient 8 months after spinal cord injury: A case report. International Journal of Immunopathology and Pharmacology, 24(3), 749-759.

Transcriptional profile of denervated vastus lateralis muscle derived from a patient 8 months after spinal cord injury : A case report. / Mancinelli, R.; Kern, H.; Fulle, S.; Carraro, U.; Zampieri, S.; Rovere, R. L A; Fanò, G.; Pietrangelo, T.

In: International Journal of Immunopathology and Pharmacology, Vol. 24, No. 3, 07.2011, p. 749-759.

Research output: Contribution to journalArticle

Mancinelli, R, Kern, H, Fulle, S, Carraro, U, Zampieri, S, Rovere, RLA, Fanò, G & Pietrangelo, T 2011, 'Transcriptional profile of denervated vastus lateralis muscle derived from a patient 8 months after spinal cord injury: A case report', International Journal of Immunopathology and Pharmacology, vol. 24, no. 3, pp. 749-759.
Mancinelli, R. ; Kern, H. ; Fulle, S. ; Carraro, U. ; Zampieri, S. ; Rovere, R. L A ; Fanò, G. ; Pietrangelo, T. / Transcriptional profile of denervated vastus lateralis muscle derived from a patient 8 months after spinal cord injury : A case report. In: International Journal of Immunopathology and Pharmacology. 2011 ; Vol. 24, No. 3. pp. 749-759.
@article{d38b9432cb404cc6b7a7c3537897488f,
title = "Transcriptional profile of denervated vastus lateralis muscle derived from a patient 8 months after spinal cord injury: A case report",
abstract = "A lack of motor neurons abolishes both neurotrophic factor secretion and contractile activity in muscle, which impairs mass, contractile properties, and fibre-type characteristics of the muscle. However, the molecular pathways that can be stimulated or repressed in the scenario of spinal cord injury remain unknown. We investigated for the first time the transcriptional profile of a young male patient 8 months after spinal cord injury. Adaptive metabolic changes of complete denervated skeletal muscle were revealed. In particular, the main molecular pathways involved include metabolic and proteolitic pathways, mitochondrial and synaptic function, calcium homeostasis, sarcomere and anchorage structures. Our data depict the molecular signalling still present in complete denervated skeletal muscle fibres a few months after spinal cord injury. These data could be of interest also to design a specific therapeutic approach aimed at the electrical-stimulation of severe atrophied skeletal muscle.",
keywords = "Atrophy, Spinal cord injury, Transcriptoma",
author = "R. Mancinelli and H. Kern and S. Fulle and U. Carraro and S. Zampieri and Rovere, {R. L A} and G. Fan{\`o} and T. Pietrangelo",
year = "2011",
month = "7",
language = "English",
volume = "24",
pages = "749--759",
journal = "International Journal of Immunopathology and Pharmacology",
issn = "0394-6320",
publisher = "Biomedical Research Press s.a.s.",
number = "3",

}

TY - JOUR

T1 - Transcriptional profile of denervated vastus lateralis muscle derived from a patient 8 months after spinal cord injury

T2 - A case report

AU - Mancinelli, R.

AU - Kern, H.

AU - Fulle, S.

AU - Carraro, U.

AU - Zampieri, S.

AU - Rovere, R. L A

AU - Fanò, G.

AU - Pietrangelo, T.

PY - 2011/7

Y1 - 2011/7

N2 - A lack of motor neurons abolishes both neurotrophic factor secretion and contractile activity in muscle, which impairs mass, contractile properties, and fibre-type characteristics of the muscle. However, the molecular pathways that can be stimulated or repressed in the scenario of spinal cord injury remain unknown. We investigated for the first time the transcriptional profile of a young male patient 8 months after spinal cord injury. Adaptive metabolic changes of complete denervated skeletal muscle were revealed. In particular, the main molecular pathways involved include metabolic and proteolitic pathways, mitochondrial and synaptic function, calcium homeostasis, sarcomere and anchorage structures. Our data depict the molecular signalling still present in complete denervated skeletal muscle fibres a few months after spinal cord injury. These data could be of interest also to design a specific therapeutic approach aimed at the electrical-stimulation of severe atrophied skeletal muscle.

AB - A lack of motor neurons abolishes both neurotrophic factor secretion and contractile activity in muscle, which impairs mass, contractile properties, and fibre-type characteristics of the muscle. However, the molecular pathways that can be stimulated or repressed in the scenario of spinal cord injury remain unknown. We investigated for the first time the transcriptional profile of a young male patient 8 months after spinal cord injury. Adaptive metabolic changes of complete denervated skeletal muscle were revealed. In particular, the main molecular pathways involved include metabolic and proteolitic pathways, mitochondrial and synaptic function, calcium homeostasis, sarcomere and anchorage structures. Our data depict the molecular signalling still present in complete denervated skeletal muscle fibres a few months after spinal cord injury. These data could be of interest also to design a specific therapeutic approach aimed at the electrical-stimulation of severe atrophied skeletal muscle.

KW - Atrophy

KW - Spinal cord injury

KW - Transcriptoma

UR - http://www.scopus.com/inward/record.url?scp=80055108559&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80055108559&partnerID=8YFLogxK

M3 - Article

C2 - 21978686

AN - SCOPUS:80055108559

VL - 24

SP - 749

EP - 759

JO - International Journal of Immunopathology and Pharmacology

JF - International Journal of Immunopathology and Pharmacology

SN - 0394-6320

IS - 3

ER -