Transcriptional regulation by mutant p53 and oncogenesis

Research output: Contribution to journalArticle

Abstract

More than half of all human cancers carry p53 gene mutations whose resulting proteins are mostly full-length with a single aminoacid change, abundantly present in cancer cells and unable to exert oncosuppressor activities. Frequently, mutant p53 proteins gain oncogenic functions through which they actively contribute to the establishment, the maintenance and the spreading of a given cancer cell. Intense research effort has been devoted to the deciphering of the molecular mechanisms underlying the gain of function of mutant p53 proteins. Here we mainly review the oncogenic transcriptional activity of mutant p53 proteins that mainly occurs through the aberrant cooperation with bona-fide transcription factors and leads to either aberrant up-regulation or down-regulation of selected target genes. Thus, mutant p53 proteins are critical components of oncogenic transcriptional networks that have a profound impact in human cancers.

Original languageEnglish
Pages (from-to)91-103
Number of pages13
JournalSub-Cellular Biochemistry
Volume85
DOIs
Publication statusPublished - 2014

Fingerprint

Mutant Proteins
Carcinogenesis
Neoplasms
Proteins
Genes
Cells
Gene Regulatory Networks
p53 Genes
Transcription Factors
Up-Regulation
Down-Regulation
Maintenance
Mutation
Research

Keywords

  • Cancer
  • Mutant p53
  • Mutation
  • Target
  • Transcription

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Cancer Research
  • Molecular Biology
  • Medicine(all)

Cite this

Transcriptional regulation by mutant p53 and oncogenesis. / Santoro, Raffaela; Strano, Sabrina; Blandino, Giovanni.

In: Sub-Cellular Biochemistry, Vol. 85, 2014, p. 91-103.

Research output: Contribution to journalArticle

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