TY - JOUR
T1 - Transcriptional regulation of macrophage polarization
T2 - Enabling diversity with identity
AU - Lawrence, Toby
AU - Natoli, Gioacchino
PY - 2011/11
Y1 - 2011/11
N2 - In terms of both phenotype and function, macrophages have remarkable heterogeneity, which reflects the specialization of tissue-resident macrophages in microenvironments as different as liver, brain and bone. Also, marked changes in the activity and gene expression programmes of macrophages can occur when they come into contact with invading microorganisms or injured tissues. Therefore, the macrophage lineage includes a remarkable diversity of cells with different functions and functional states that are specified by a complex interplay between microenvironmental signals and a hardwired differentiation programme that determines macrophage identity. In this Review, we summarize the current knowledge of transcriptional and chromatin-mediated control of macrophage polarization in physiology and disease.
AB - In terms of both phenotype and function, macrophages have remarkable heterogeneity, which reflects the specialization of tissue-resident macrophages in microenvironments as different as liver, brain and bone. Also, marked changes in the activity and gene expression programmes of macrophages can occur when they come into contact with invading microorganisms or injured tissues. Therefore, the macrophage lineage includes a remarkable diversity of cells with different functions and functional states that are specified by a complex interplay between microenvironmental signals and a hardwired differentiation programme that determines macrophage identity. In this Review, we summarize the current knowledge of transcriptional and chromatin-mediated control of macrophage polarization in physiology and disease.
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U2 - 10.1038/nri3088
DO - 10.1038/nri3088
M3 - Article
C2 - 22025054
AN - SCOPUS:80355146399
VL - 11
SP - 750
EP - 761
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
SN - 1474-1733
IS - 11
ER -