Transcriptional Regulation of Metabolic Pathways via Lipid-Sensing Nuclear Receptors PPARs, FXR, and LXR in NASH

Marica Cariello, Elena Piccinin, Antonio Moschetta

Research output: Contribution to journalReview articlepeer-review

Abstract

Nonalcoholic fatty liver disease comprises a wide spectrum of liver injuries from simple steatosis to steatohepatitis and cirrhosis. Nonalcoholic steatohepatitis (NASH) is defined when liver steatosis is associated with inflammation, hepatocyte damage, and fibrosis. A genetic predisposition and environmental insults (ie, dietary habits, obesity) are putatively responsible for NASH progression. Here, we present the impact of the lipid-sensing nuclear receptors in the pathogenesis and treatment of NASH. In detail, we discuss the pros and cons of the putative transcriptional action of the fatty acid sensors (peroxisome proliferator-activated receptors), the bile acid sensor (farnesoid X receptor), and the oxysterol sensor (liver X receptors) in the pathogenesis and bona fide treatment of NASH.

Original languageEnglish
Pages (from-to)1519-1539
Number of pages21
JournalCMGH
Volume11
Issue number5
DOIs
Publication statusPublished - Jan 2021

Keywords

  • Farnesoid X Receptor (FXR)
  • Liver X Receptor (LXR)
  • Nonalcoholic Steatohepatitis (NASH)
  • Nuclear Receptors
  • Peroxisome Proliferator Activated Receptors (PPARs)

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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