Transcriptional regulation of ncx1 gene in the brain

Valeria Valsecchi, Giuseppe Pignataro, Rossana Sirabella, Carmela Matrone, Francesca Boscia, Antonella Scorziello, Maria Josè Sisalli, Elga Esposito, Nicola Zambrano, Mauro Cataldi, Gianfranco Di Renzo, Lucio Annunziato

Research output: Chapter in Book/Report/Conference proceedingConference contribution


The ubiquitous sodium-calcium exchanger isoform 1 (NCX1) is a bidirectional transporter that plays a relevant role under physiological and pathophysiological conditions including brain ischemia by regulating intraneuronal Ca2+ and Na+ homeostasis. Although changes in ncx1 protein and transcript expression have been detected during stroke, its transcriptional regulation is still largely unexplored. Here, we reviewed our recent findings on several transcription factors including cAMP response element-binding protein (CREB), nuclear factor kappa B (NF-κB), and hypoxia-inducible factor-1 (HIF-1) in the control of the ncx1 gene expression in neuronal cells.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Number of pages9
Publication statusPublished - 2013

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)00652598


  • HIF-1
  • Hypoxia
  • Ischemic preconditioning
  • ncx1
  • Transcriptional regulation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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