Transcriptome of normal lung distinguishes mouse lines with different susceptibility to inflammation and to lung tumorigenesis

Marcelo De Franco, Francesca Colombo, Antonella Galvan, Loris De Cecco, Elena Spada, Silvano Milani, Olga M. Ibanez, Tommaso A. Dragani

Research output: Contribution to journalArticle

Abstract

AIRmax and AIRmin mouse lines show a differential lung inflammatory response and differential lung tumor susceptibility after urethane treatment. The transcript profile of ∼24,000 known genes was analyzed in normal lung tissue of untreated and urethane-treated AIRmax and AIRmin mice. In lungs of untreated mice, inflammation-associated genes involved in pathways such as " leukocyte transendothelial migration" , " cell adhesion" and " tight junctions" were differentially expressed. Moreover, gene expression levels differed significantly in urethane-treated mice; in AIRmin mice, modulation of expression of genes involved in pathways associated with inflammatory response paralleled the previously observed persistent infiltration of inflammatory cells in the lung of these mice.

Original languageEnglish
Pages (from-to)187-194
Number of pages8
JournalCancer Letters
Volume294
Issue number2
DOIs
Publication statusPublished - Aug 2010

Keywords

  • Animal models
  • Inflammatory response
  • Microarray
  • MRNA profile

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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