Transcriptomic analysis of covid-19 lungs and bronchoalveolar lavage fluid samples reveals predominant b cell activation responses to infection

Eugenio Cavalli, Maria Cristina Petralia, Maria Sofia Basile, Alessia Bramanti, Placido Bramanti, Ferdinando Nicoletti, Demetrios A. Spandidos, Yehuda Shoenfeld, Paolo Fagone

Research output: Contribution to journalArticle

Abstract

The outbreak of the 2019 coronavirus disease (named, COVID-19), caused by the novel SARS-coV-2 virus, represents a worldwide severe threat to public health. It is of the utmost importance to characterize the immune responses against the SARS-CoV-2 and the mechanisms of hyperinflammation, in order to design better therapeutic strategies for cOVId-19. In the present study, a transcriptomic analysis was performed to profile the immune signatures in lung and the bronchoalveolar lavage fluid samples from COVID-19 patients and controls. Our data concordantly revealed increased humoral responses to infection. The elucidation of the host responses to SARS-coV-2 infection may further improve our understanding of COVID-19 pathogenesis and suggest better therapeutic strategies.

Original languageEnglish
Pages (from-to)1266-1273
Number of pages8
JournalInternational Journal of Molecular Medicine
Volume46
Issue number4
DOIs
Publication statusPublished - Oct 2020

Keywords

  • Bioinformatics
  • COVID-19
  • Immune response
  • SARS-CoV-2

ASJC Scopus subject areas

  • Genetics

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