TY - JOUR
T1 - Transcriptomic analysis of covid-19 lungs and bronchoalveolar lavage fluid samples reveals predominant b cell activation responses to infection
AU - Cavalli, Eugenio
AU - Petralia, Maria Cristina
AU - Basile, Maria Sofia
AU - Bramanti, Alessia
AU - Bramanti, Placido
AU - Nicoletti, Ferdinando
AU - Spandidos, Demetrios A.
AU - Shoenfeld, Yehuda
AU - Fagone, Paolo
N1 - Funding Information:
This study was supported by current research funds 2020 of IRCCS Centro Neurolesi ‘Bonino‑Pulejo’, Messina, Italy.
Publisher Copyright:
© This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/10
Y1 - 2020/10
N2 - The outbreak of the 2019 coronavirus disease (named, COVID-19), caused by the novel SARS-coV-2 virus, represents a worldwide severe threat to public health. It is of the utmost importance to characterize the immune responses against the SARS-CoV-2 and the mechanisms of hyperinflammation, in order to design better therapeutic strategies for cOVId-19. In the present study, a transcriptomic analysis was performed to profile the immune signatures in lung and the bronchoalveolar lavage fluid samples from COVID-19 patients and controls. Our data concordantly revealed increased humoral responses to infection. The elucidation of the host responses to SARS-coV-2 infection may further improve our understanding of COVID-19 pathogenesis and suggest better therapeutic strategies.
AB - The outbreak of the 2019 coronavirus disease (named, COVID-19), caused by the novel SARS-coV-2 virus, represents a worldwide severe threat to public health. It is of the utmost importance to characterize the immune responses against the SARS-CoV-2 and the mechanisms of hyperinflammation, in order to design better therapeutic strategies for cOVId-19. In the present study, a transcriptomic analysis was performed to profile the immune signatures in lung and the bronchoalveolar lavage fluid samples from COVID-19 patients and controls. Our data concordantly revealed increased humoral responses to infection. The elucidation of the host responses to SARS-coV-2 infection may further improve our understanding of COVID-19 pathogenesis and suggest better therapeutic strategies.
KW - Bioinformatics
KW - COVID-19
KW - Immune response
KW - SARS-CoV-2
UR - http://www.scopus.com/inward/record.url?scp=85090605999&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85090605999&partnerID=8YFLogxK
U2 - 10.3892/ijmm.2020.4702
DO - 10.3892/ijmm.2020.4702
M3 - Article
C2 - 32945352
AN - SCOPUS:85090605999
VL - 46
SP - 1266
EP - 1273
JO - International Journal of Molecular Medicine
JF - International Journal of Molecular Medicine
SN - 1107-3756
IS - 4
ER -