Transcriptomic and genomic features of invasive lobular breast cancer

Christine Desmedt, Gabriele Zoppoli, Christos Sotiriou, Roberto Salgado

Research output: Contribution to journalReview article

Abstract

Accounting for 10–15% of all breast neoplasms, invasive lobular breast cancer (ILC) is the second most common histological subtype of breast cancer after invasive ductal breast cancer (IDC). Understanding ILC biology, which differs from IDC in terms of clinical presentation, treatment response, relapse timing and patterns, is essential in order to adopt novel, disease-specific management strategies. While the contribution of the histological subtypes to tumour biology has been poorly investigated and acknowledged in the past, recently several major, independent efforts have led to the assembly and molecular characterization of well-annotated ILC case sets. In this review, we provide a critical overview of the literature exploring ILC, through comprehensive and multiomic methods. The first part specifically focuses on ILC transcriptomic features by reviewing the intrinsic molecular subtypes, the application of gene expression scores for the prediction of recurrence, and the identification of gene expression subtypes. The second part describes the main research efforts that lead to the identification of the genomic landscape of ILC, with a special focus to findings that differentiate ILC from IDC and carry potential clinical relevance.

Original languageEnglish
Pages (from-to)98-105
Number of pages8
JournalSeminars in Cancer Biology
Volume44
DOIs
Publication statusPublished - Jun 1 2017

Keywords

  • Gene expression
  • Immune
  • Intrinsic subtypes
  • Invasive lobular breast cancer
  • mutations
  • Prognostic classifiers
  • Proteomics
  • Sequencing

ASJC Scopus subject areas

  • Cancer Research

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