La transcriptómica ilustra nuevas vías letales en la nefropatía diabética

Translated title of the contribution: Transcriptomics illustrate a deadly TRAIL to diabetic nephropathy

A. Benito-Martín, A. C. Ucero, B. Santamaría, C. Lorz, M. Kretzler, M. P. Rastaldi, M. D. Sánchez-Niño, A. Sanz, M. C. Izquierdo, M. Ruiz-Ortega, J. Egido, A. Ortiz

Research output: Contribution to journalArticlepeer-review

Abstract

Diabetic nephropathy is the most common cause of endstage renal disease. Approaches targeting angiotensin II significantly delay its progression. However, many patients still need renal replacement therapy. High throughput techniques such as unbiased gene expression profiling and proteomics may identify new therapeutic targets. Cell death is thought to contribute to progressive renal cell depletion in chronic nephropathies. A European collaborative effort recently applied renal biopsy transcriptomics to identify novel mediators of renal cell death in diabetic nephropathy. Twenty-five percent of cell death regulatory genes were upor downregulated in diabetic kidneys. TNF-related apoptosisinducing ligand (TRAIL) and osteoprotegerin had the highest level of expression. In diabetic nephropathy, tubular cells and podocytes express TRAIL. Inflammatory cytokines, including MIF via CD74, upregulate TRAIL. A high glucose environment sensitized renal cells to the lethal effect of TRAIL, while osteoprotegerin is protective. These results suggest that, in addition to glucose levels, inflammation and TRAIL are therapeutic targets in diabetic nephropathy.

Translated title of the contributionTranscriptomics illustrate a deadly TRAIL to diabetic nephropathy
Original languageSpanish
Pages (from-to)13-19
Number of pages7
JournalNefrologia
Volume29
Issue number1
Publication statusPublished - 2009

Keywords

  • Apoptosis
  • CD74
  • Diabetes
  • Kidney
  • MIF
  • TRAIL

ASJC Scopus subject areas

  • Nephrology

Fingerprint Dive into the research topics of 'Transcriptomics illustrate a deadly TRAIL to diabetic nephropathy'. Together they form a unique fingerprint.

Cite this