Transcutaneous oxygen tension as a potential predictor of cardiovascular events in type 2 diabetes: Comparison with ankle-brachial index

Carmine Gazzaruso, Adriana Coppola, Colomba Falcone, Chiara Luppi, Tiziana Montalcini, Elisabetta Baffero, Pietro Gallotti, Arturo Pujia, Sebastiano B. Solerte, Gabriele Pelissero, Andrea Giustina

Research output: Contribution to journalArticle

Abstract

OBJECTIVE - Transcutaneous oxygen tension (TcPO2) measures tissue perfusion and is important in the management of peripheral artery disease (PAD). Ankle brachial index (ABI) is used for the diagnosis of PAD and represents a predictor of major adverse cardiovascular events (MACE), even if in diabetes its diagnostic and predictive value seems to be reduced. No study has evaluated TcPO2 as a predictor of cardiovascular events. Aim of this longitudinal study was to assess whether TcPO2 is better than ABI at predicting MACE in type 2 diabetic patients. RESEARCH DESIGN AND METHODS - Among 361 consecutive patients with apparently uncomplicated diabetes, 67 MACE occurred during a follow-up period of 45.8 ± 23.2 months. RESULTS - The percentage of both subjects with low ABI (≤0.9) and subjects with low TcPO2 (≤46 mmHg as measured by a receiver operating characteristic curve) was significantly ( 0.0001) were associated with a higher rate of MACEs. Cox regression analysis showed that low TcPO2 (hazard ratio 1.78 [95% CI 1.44-2.23]; P <0.001) was a significant predictor of MACE, while ABI did not enter the model. CONCLUSIONS - This longitudinal study showed that TcPO2 may be a potential predictor of MACE among patients with uncomplicated type 2 diabetes and that its predictive value seems to be greater than that of ABI.

Original languageEnglish
Pages (from-to)1720-1725
Number of pages6
JournalDiabetes Care
Volume36
Issue number6
DOIs
Publication statusPublished - Jun 2013

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ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

Cite this

Gazzaruso, C., Coppola, A., Falcone, C., Luppi, C., Montalcini, T., Baffero, E., Gallotti, P., Pujia, A., Solerte, S. B., Pelissero, G., & Giustina, A. (2013). Transcutaneous oxygen tension as a potential predictor of cardiovascular events in type 2 diabetes: Comparison with ankle-brachial index. Diabetes Care, 36(6), 1720-1725. https://doi.org/10.2337/dc12-1401