Transdermal hormonal therapy in perimenstrual migraine: Why, when and how

Research output: Contribution to journalArticlepeer-review

Abstract

Experimental and clinical evidence is strongly in favor of a role for estrogens in migraine. It is clear that estrogen fluctuations represent trigger factors for the attacks, while the resolution of these fluctuations (menopause) may be associated to the remission or, conversely, to the worsening of the disease. However, the exact mechanisms and mediators underlying the effects of estrogens in migraine are largely unknown. The exact mechanisms and mediators underlying the effects of estrogens in migraine are largely unknown. In this review, we summarize clinical and preclinical data that are relevant for the role of estrogens in migraine and we discuss how estrogen modulation can be exploited positively to improve hormonal-related migraine.

Original languageEnglish
Pages (from-to)467-473
Number of pages7
JournalCurrent Pain and Headache Reports
Volume16
Issue number5
DOIs
Publication statusPublished - Oct 2012

Keywords

  • Estrogens
  • Menstrual
  • Migraine
  • Pain
  • Transdermal

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine

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