Transepithelial iontophoresis versus standard corneal collagen cross-linking: 1-year results of a prospective clinical study

Paolo Vinciguerra, Vito Romano, Pietro Rosetta, Emanuela F. Legrottaglie, Raffaele Piscopo, Claudia Fabiani, Claudio Azzolini, Riccardo Vinciguerra

Research output: Contribution to journalArticle

Abstract

PURPOSE: To compare 1-year transepithelial corneal collagen cross-linking with iontophoresis (I-CXL) outcomes with standard CXL (S-CXL) epithelium-off for progressive keratoconus. METHODS: Forty eyes of 40 patients with progressive keratoconus were included in this comparative, prospective clinical study. Corrected distance visual acuity (CDVA), spherical equivalent, cylinder refraction, cor-neal topography, Scheimpfug tomography, aberrometry, and endothelial cell count were assessed at baseline and at 1, 3, 6, and 12 months of follow-up. RESULTS: Patients received either I-CXL (20 eyes) or S-CXL (20 eyes). Functional parameters (visual acuity and aberrometry) showed a significant improvement (P <. 05) after 6 and 12 months of follow-up in both groups. In the I-CXL group, the CDVA showed a rapid recovery of vision after 3 months (P =. 01) compared to baseline. Morphological parameters showed a significant reduction of maximum keratometry in the S-CXL group by -1.05 ± 1.51 diopters (D) after 12 months, whereas the I-CXL group curvature was stable (-0.31 ± 1.87 D). Minimum pachymetry values were stable even after 12 months of follow-up in the I-CXL group, whereas a significant corneal thinning 12 months following treatment was recorded in the S-CXL group (P <. 001). None of the patients had continuous progression of keratoconus or had to repeat CXL procedures. Endothelial cell counts did not change significantly (P >. 05). CONCLUSIONS: The 1-year outcomes suggest that I-CXL might be comparable to S-CXL in stabilizing the progression of the degenerative ectatic disease. Additionally, quicker improvement of functional parameters was reported in the I-CXL group.

Original languageEnglish
Pages (from-to)672-678
Number of pages7
JournalJournal of Refractive Surgery
Volume32
Issue number10
DOIs
Publication statusPublished - Oct 1 2016

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Iontophoresis
Aberrometry
Keratoconus
Collagen
Prospective Studies
Visual Acuity
Epithelium
Endothelial Cells
Cell Count
Tomography
Clinical Studies

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

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Transepithelial iontophoresis versus standard corneal collagen cross-linking : 1-year results of a prospective clinical study. / Vinciguerra, Paolo; Romano, Vito; Rosetta, Pietro; Legrottaglie, Emanuela F.; Piscopo, Raffaele; Fabiani, Claudia; Azzolini, Claudio; Vinciguerra, Riccardo.

In: Journal of Refractive Surgery, Vol. 32, No. 10, 01.10.2016, p. 672-678.

Research output: Contribution to journalArticle

Vinciguerra, Paolo ; Romano, Vito ; Rosetta, Pietro ; Legrottaglie, Emanuela F. ; Piscopo, Raffaele ; Fabiani, Claudia ; Azzolini, Claudio ; Vinciguerra, Riccardo. / Transepithelial iontophoresis versus standard corneal collagen cross-linking : 1-year results of a prospective clinical study. In: Journal of Refractive Surgery. 2016 ; Vol. 32, No. 10. pp. 672-678.
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AU - Legrottaglie, Emanuela F.

AU - Piscopo, Raffaele

AU - Fabiani, Claudia

AU - Azzolini, Claudio

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