Transethnic genome-wide association study provides insights in the genetic architecture and heritability of long QT syndrome

N. Lahrouchi; R. Tadros; L. Crotti; Y. Mizusawa; P.G. Postema; L. Beekman; R. Walsh; K. Hasegawa; J. Barc; M. Ernsting; K.L. Turkowski; A. Mazzanti; B.M. Beckmann; K. Shimamoto; U.-B. Diamant; Y.D. Wijeyeratne; Y. Kucho; T. Robyns; T. Ishikawa; E. Arbelo; M. Christiansen; A. Winbo; R. Jabbari; S.A. Lubitz; J. Steinfurt; B. Rudic; B. Loeys; M.B. Shoemaker; P.E. Weeke; R. Pfeiffer; B. Davies; A. Andorin; N. Hofman; F. Dagradi; M. Pedrazzini; D.J. Tester; J.M. Bos; G. Sarquella-Brugada; O. Campuzano; P.G. Platonov; B. Stallmeyer; S. Zumhagen; E.A. Nannenberg; J.H. Veldink; L.H. Van Den Berg; A. Al-Chalabi; C.E. Shaw; P.J. Shaw; K.E. Morrison; P.M. Andersen; M. Müller-Nurasyid; D. Cusi; C. Barlassina; P. Galan; M. Lathrop; M. Munter; T. Werge; M. Ribasés; T. Aung; C.C. Khor; M. Ozaki; P. Lichtner; T. Meitinger; J.P. Van Tintelen; Y. Hoedemaekers; I. Denjoy; A. Leenhardt; C. Napolitano; W. Shimizu; J.-J. Schott; J.-B. Gourraud; T. Makiyama; S. Ohno; H. Itoh; A.D. Krahn; C. Antzelevitch; D.M. Roden; J. Saenen; M. Borggrefe; K.E. Odening; P.T. Ellinor; J. Tfelt-Hansen; J.R. Skinner; M.P. Van Den Berg; M.S. Olesen; J. Brugada; R. Brugada; N. Makita; J. Breckpot; M. Yoshinaga; E.R. Behr; A. Rydberg; T. Aiba; S. Kääb; S.G. Priori; P. Guicheney; H.L. Tan; C. Newton-Cheh; M.J. Ackerman; P.J. Schwartz; E. Schulze-Bahr; V. Probst; M. Horie; A.A. Wilde; M.W.T. Tanck; C.R. Bezzina

doi:10.1161/CIRCULATIONAHA.120.045956

Transethnic genome-wide association study provides insights in the genetic architecture and heritability of long QT syndrome

N. Lahrouchi, R. Tadros, L. Crotti, Y. Mizusawa, P.G. Postema, L. Beekman, R. Walsh, K. Hasegawa, J. Barc, M. Ernsting, K.L. Turkowski, A. Mazzanti, B.M. Beckmann, K. Shimamoto, U.-B. Diamant, Y.D. Wijeyeratne, Y. Kucho, T. Robyns, T. Ishikawa, E. ArbeloM. Christiansen, A. Winbo, R. Jabbari, S.A. Lubitz, J. Steinfurt, B. Rudic, B. Loeys, M.B. Shoemaker, P.E. Weeke, R. Pfeiffer, B. Davies, A. Andorin, N. Hofman, F. Dagradi, M. Pedrazzini, D.J. Tester, J.M. Bos, G. Sarquella-Brugada, O. Campuzano, P.G. Platonov, B. Stallmeyer, S. Zumhagen, E.A. Nannenberg, J.H. Veldink, L.H. Van Den Berg, A. Al-Chalabi, C.E. Shaw, P.J. Shaw, K.E. Morrison, P.M. Andersen, M. Müller-Nurasyid, D. Cusi, C. Barlassina, P. Galan, M. Lathrop, M. Munter, T. Werge, M. Ribasés, T. Aung, C.C. Khor, M. Ozaki, P. Lichtner, T. Meitinger, J.P. Van Tintelen, Y. Hoedemaekers, I. Denjoy, A. Leenhardt, C. Napolitano, W. Shimizu, J.-J. Schott, J.-B. Gourraud, T. Makiyama, S. Ohno, H. Itoh, A.D. Krahn, C. Antzelevitch, D.M. Roden, J. Saenen, M. Borggrefe, K.E. Odening, P.T. Ellinor, J. Tfelt-Hansen, J.R. Skinner, M.P. Van Den Berg, M.S. Olesen, J. Brugada, R. Brugada, N. Makita, J. Breckpot, M. Yoshinaga, E.R. Behr, A. Rydberg, T. Aiba, S. Kääb, S.G. Priori, P. Guicheney, H.L. Tan, C. Newton-Cheh, M.J. Ackerman, P.J. Schwartz, E. Schulze-Bahr, V. Probst, M. Horie, A.A. Wilde, M.W.T. Tanck, C.R. Bezzina

Research output: Contribution to journal › Article › peer-review

Original language	Italian
Pages (from-to)	324-338
Number of pages	15
Journal	Circulation
Volume	142
Issue number	4
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.120.045956
Publication status	Published - 2020

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10.1161/CIRCULATIONAHA.120.045956

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85088849122&doi=10.1161%2fCIRCULATIONAHA.120.045956&partnerID=40&md5=205d5bf72ee96183920b45e612dcda9a

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Lahrouchi, N., Tadros, R., Crotti, L., Mizusawa, Y., Postema, P. G., Beekman, L., Walsh, R., Hasegawa, K., Barc, J., Ernsting, M., Turkowski, K. L., Mazzanti, A., Beckmann, B. M., Shimamoto, K., Diamant, U-B., Wijeyeratne, Y. D., Kucho, Y., Robyns, T., Ishikawa, T., ... Bezzina, C. R. (2020). Transethnic genome-wide association study provides insights in the genetic architecture and heritability of long QT syndrome. Circulation, 142(4), 324-338. https://doi.org/10.1161/CIRCULATIONAHA.120.045956

Transethnic genome-wide association study provides insights in the genetic architecture and heritability of long QT syndrome. / Lahrouchi, N.; Tadros, R.; Crotti, L.; Mizusawa, Y.; Postema, P.G.; Beekman, L.; Walsh, R.; Hasegawa, K.; Barc, J.; Ernsting, M.; Turkowski, K.L.; Mazzanti, A.; Beckmann, B.M.; Shimamoto, K.; Diamant, U.-B.; Wijeyeratne, Y.D.; Kucho, Y.; Robyns, T.; Ishikawa, T.; Arbelo, E.; Christiansen, M.; Winbo, A.; Jabbari, R.; Lubitz, S.A.; Steinfurt, J.; Rudic, B.; Loeys, B.; Shoemaker, M.B.; Weeke, P.E.; Pfeiffer, R.; Davies, B.; Andorin, A.; Hofman, N.; Dagradi, F.; Pedrazzini, M.; Tester, D.J.; Bos, J.M.; Sarquella-Brugada, G.; Campuzano, O.; Platonov, P.G.; Stallmeyer, B.; Zumhagen, S.; Nannenberg, E.A.; Veldink, J.H.; Van Den Berg, L.H.; Al-Chalabi, A.; Shaw, C.E.; Shaw, P.J.; Morrison, K.E.; Andersen, P.M.; Müller-Nurasyid, M.; Cusi, D.; Barlassina, C.; Galan, P.; Lathrop, M.; Munter, M.; Werge, T.; Ribasés, M.; Aung, T.; Khor, C.C.; Ozaki, M.; Lichtner, P.; Meitinger, T.; Van Tintelen, J.P.; Hoedemaekers, Y.; Denjoy, I.; Leenhardt, A.; Napolitano, C.; Shimizu, W.; Schott, J.-J.; Gourraud, J.-B.; Makiyama, T.; Ohno, S.; Itoh, H.; Krahn, A.D.; Antzelevitch, C.; Roden, D.M.; Saenen, J.; Borggrefe, M.; Odening, K.E.; Ellinor, P.T.; Tfelt-Hansen, J.; Skinner, J.R.; Van Den Berg, M.P.; Olesen, M.S.; Brugada, J.; Brugada, R.; Makita, N.; Breckpot, J.; Yoshinaga, M.; Behr, E.R.; Rydberg, A.; Aiba, T.; Kääb, S.; Priori, S.G.; Guicheney, P.; Tan, H.L.; Newton-Cheh, C.; Ackerman, M.J.; Schwartz, P.J.; Schulze-Bahr, E.; Probst, V.; Horie, M.; Wilde, A.A.; Tanck, M.W.T.; Bezzina, C.R.

In: Circulation, Vol. 142, No. 4, 2020, p. 324-338.

Research output: Contribution to journal › Article › peer-review

Lahrouchi, N, Tadros, R, Crotti, L, Mizusawa, Y, Postema, PG, Beekman, L, Walsh, R, Hasegawa, K, Barc, J, Ernsting, M, Turkowski, KL, Mazzanti, A, Beckmann, BM, Shimamoto, K, Diamant, U-B, Wijeyeratne, YD, Kucho, Y, Robyns, T, Ishikawa, T, Arbelo, E, Christiansen, M, Winbo, A, Jabbari, R, Lubitz, SA, Steinfurt, J, Rudic, B, Loeys, B, Shoemaker, MB, Weeke, PE, Pfeiffer, R, Davies, B, Andorin, A, Hofman, N, Dagradi, F , Pedrazzini, M, Tester, DJ, Bos, JM, Sarquella-Brugada, G, Campuzano, O, Platonov, PG, Stallmeyer, B, Zumhagen, S, Nannenberg, EA, Veldink, JH, Van Den Berg, LH, Al-Chalabi, A, Shaw, CE, Shaw, PJ, Morrison, KE, Andersen, PM, Müller-Nurasyid, M, Cusi, D, Barlassina, C, Galan, P, Lathrop, M, Munter, M, Werge, T, Ribasés, M, Aung, T, Khor, CC, Ozaki, M, Lichtner, P, Meitinger, T, Van Tintelen, JP, Hoedemaekers, Y, Denjoy, I, Leenhardt, A, Napolitano, C, Shimizu, W, Schott, J-J, Gourraud, J-B, Makiyama, T, Ohno, S, Itoh, H, Krahn, AD, Antzelevitch, C, Roden, DM, Saenen, J, Borggrefe, M, Odening, KE, Ellinor, PT, Tfelt-Hansen, J, Skinner, JR, Van Den Berg, MP, Olesen, MS, Brugada, J, Brugada, R, Makita, N, Breckpot, J, Yoshinaga, M, Behr, ER, Rydberg, A, Aiba, T, Kääb, S, Priori, SG, Guicheney, P, Tan, HL, Newton-Cheh, C, Ackerman, MJ, Schwartz, PJ, Schulze-Bahr, E, Probst, V, Horie, M, Wilde, AA, Tanck, MWT & Bezzina, CR 2020, 'Transethnic genome-wide association study provides insights in the genetic architecture and heritability of long QT syndrome', Circulation, vol. 142, no. 4, pp. 324-338. https://doi.org/10.1161/CIRCULATIONAHA.120.045956

Lahrouchi, N. ; Tadros, R. ; Crotti, L. ; Mizusawa, Y. ; Postema, P.G. ; Beekman, L. ; Walsh, R. ; Hasegawa, K. ; Barc, J. ; Ernsting, M. ; Turkowski, K.L. ; Mazzanti, A. ; Beckmann, B.M. ; Shimamoto, K. ; Diamant, U.-B. ; Wijeyeratne, Y.D. ; Kucho, Y. ; Robyns, T. ; Ishikawa, T. ; Arbelo, E. ; Christiansen, M. ; Winbo, A. ; Jabbari, R. ; Lubitz, S.A. ; Steinfurt, J. ; Rudic, B. ; Loeys, B. ; Shoemaker, M.B. ; Weeke, P.E. ; Pfeiffer, R. ; Davies, B. ; Andorin, A. ; Hofman, N. ; Dagradi, F. ; Pedrazzini, M. ; Tester, D.J. ; Bos, J.M. ; Sarquella-Brugada, G. ; Campuzano, O. ; Platonov, P.G. ; Stallmeyer, B. ; Zumhagen, S. ; Nannenberg, E.A. ; Veldink, J.H. ; Van Den Berg, L.H. ; Al-Chalabi, A. ; Shaw, C.E. ; Shaw, P.J. ; Morrison, K.E. ; Andersen, P.M. ; Müller-Nurasyid, M. ; Cusi, D. ; Barlassina, C. ; Galan, P. ; Lathrop, M. ; Munter, M. ; Werge, T. ; Ribasés, M. ; Aung, T. ; Khor, C.C. ; Ozaki, M. ; Lichtner, P. ; Meitinger, T. ; Van Tintelen, J.P. ; Hoedemaekers, Y. ; Denjoy, I. ; Leenhardt, A. ; Napolitano, C. ; Shimizu, W. ; Schott, J.-J. ; Gourraud, J.-B. ; Makiyama, T. ; Ohno, S. ; Itoh, H. ; Krahn, A.D. ; Antzelevitch, C. ; Roden, D.M. ; Saenen, J. ; Borggrefe, M. ; Odening, K.E. ; Ellinor, P.T. ; Tfelt-Hansen, J. ; Skinner, J.R. ; Van Den Berg, M.P. ; Olesen, M.S. ; Brugada, J. ; Brugada, R. ; Makita, N. ; Breckpot, J. ; Yoshinaga, M. ; Behr, E.R. ; Rydberg, A. ; Aiba, T. ; Kääb, S. ; Priori, S.G. ; Guicheney, P. ; Tan, H.L. ; Newton-Cheh, C. ; Ackerman, M.J. ; Schwartz, P.J. ; Schulze-Bahr, E. ; Probst, V. ; Horie, M. ; Wilde, A.A. ; Tanck, M.W.T. ; Bezzina, C.R. / Transethnic genome-wide association study provides insights in the genetic architecture and heritability of long QT syndrome. In: Circulation. 2020 ; Vol. 142, No. 4. pp. 324-338.

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AU - Lahrouchi, N.

AU - Tadros, R.

AU - Crotti, L.

AU - Mizusawa, Y.

AU - Postema, P.G.

AU - Beekman, L.

AU - Walsh, R.

AU - Hasegawa, K.

AU - Barc, J.

AU - Ernsting, M.

AU - Turkowski, K.L.

AU - Mazzanti, A.

AU - Beckmann, B.M.

AU - Shimamoto, K.

AU - Diamant, U.-B.

AU - Wijeyeratne, Y.D.

AU - Kucho, Y.

AU - Robyns, T.

AU - Ishikawa, T.

AU - Arbelo, E.

AU - Christiansen, M.

AU - Winbo, A.

AU - Jabbari, R.

AU - Lubitz, S.A.

AU - Steinfurt, J.

AU - Rudic, B.

AU - Loeys, B.

AU - Shoemaker, M.B.

AU - Weeke, P.E.

AU - Pfeiffer, R.

AU - Davies, B.

AU - Andorin, A.

AU - Hofman, N.

AU - Dagradi, F.

AU - Pedrazzini, M.

AU - Tester, D.J.

AU - Bos, J.M.

AU - Sarquella-Brugada, G.

AU - Campuzano, O.

AU - Platonov, P.G.

AU - Stallmeyer, B.

AU - Zumhagen, S.

AU - Nannenberg, E.A.

AU - Veldink, J.H.

AU - Van Den Berg, L.H.

AU - Al-Chalabi, A.

AU - Shaw, C.E.

AU - Shaw, P.J.

AU - Morrison, K.E.

AU - Andersen, P.M.

AU - Müller-Nurasyid, M.

AU - Cusi, D.

AU - Barlassina, C.

AU - Galan, P.

AU - Lathrop, M.

AU - Munter, M.

AU - Werge, T.

AU - Ribasés, M.

AU - Aung, T.

AU - Khor, C.C.

AU - Ozaki, M.

AU - Lichtner, P.

AU - Meitinger, T.

AU - Van Tintelen, J.P.

AU - Hoedemaekers, Y.

AU - Denjoy, I.

AU - Leenhardt, A.

AU - Napolitano, C.

AU - Shimizu, W.

AU - Schott, J.-J.

AU - Gourraud, J.-B.

AU - Makiyama, T.

AU - Ohno, S.

AU - Itoh, H.

AU - Krahn, A.D.

AU - Antzelevitch, C.

AU - Roden, D.M.

AU - Saenen, J.

AU - Borggrefe, M.

AU - Odening, K.E.

AU - Ellinor, P.T.

AU - Tfelt-Hansen, J.

AU - Skinner, J.R.

AU - Van Den Berg, M.P.

AU - Olesen, M.S.

AU - Brugada, J.

AU - Brugada, R.

AU - Makita, N.

AU - Breckpot, J.

AU - Yoshinaga, M.

AU - Behr, E.R.

AU - Rydberg, A.

AU - Aiba, T.

AU - Kääb, S.

AU - Priori, S.G.

AU - Guicheney, P.

AU - Tan, H.L.

AU - Newton-Cheh, C.

AU - Ackerman, M.J.

AU - Schwartz, P.J.

AU - Schulze-Bahr, E.

AU - Probst, V.

AU - Horie, M.

AU - Wilde, A.A.

AU - Tanck, M.W.T.

AU - Bezzina, C.R.

N1 - Cited By :5 Export Date: 4 February 2021

PY - 2020

Y1 - 2020

U2 - 10.1161/CIRCULATIONAHA.120.045956

DO - 10.1161/CIRCULATIONAHA.120.045956

M3 - Articolo

VL - 142

SP - 324

EP - 338

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 4

ER -