Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer’s disease

M.C. Dalmasso, L.I. Brusco, N. Olivar, C. Muchnik, C. Hanses, E. Milz, J. Becker, S. Heilmann-Heimbach, P. Hoffmann, F.A. Prestia, P. Galeano, M.S.S. Avalos, L.E. Martinez, M.E. Carulla, P.J. Azurmendi, C. Liberczuk, C. Fezza, M. Sampaño, M. Fierens, G. JemarP. Solis, N. Medel, J. Lisso, Z. Sevillano, P. Bosco, P. Bossù, G. Spalletta, D. Galimberti, M. Mancuso, B. Nacmias, S. Sorbi, P. Mecocci, A. Pilotto, P. Caffarra, F. Panza, M. Bullido, J. Clarimon, P. Sánchez-Juan, E. Coto, F. Sanchez-Garcia, C. Graff, M. Ingelsson, C. Bellenguez, E.M. Castaño, C. Kairiyama, D.G. Politis, S. Kochen, H. Scaro, W. Maier, F. Jessen, C.A. Mangone, J.-C. Lambert, L. Morelli, A. Ramirez

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Article number55
JournalTranslational Psychiatry
Volume9
Issue number1
DOIs
Publication statusPublished - 2019

Keywords

  • abi3 gene
  • adult
  • aged
  • Alzheimer disease
  • American Indian
  • ancestry group
  • Argentinian
  • Article
  • Caucasian
  • controlled study
  • ethnicity
  • European
  • female
  • gene frequency
  • genetic association
  • genetic susceptibility
  • genetic variability
  • genotype
  • human
  • inheritance
  • major clinical study
  • male
  • plcg2 gene
  • single nucleotide polymorphism
  • South America
  • trem2 gene
  • Yoruba (people)
  • Argentina
  • Black person
  • ethnology
  • genetic predisposition
  • genetic variation
  • genetics
  • genome-wide association study
  • meta analysis
  • middle aged
  • very elderly
  • ABI3 protein, human
  • immunoglobulin receptor
  • membrane protein
  • phospholipase C gamma
  • signal transducing adaptor protein
  • TREM2 protein, human
  • Adaptor Proteins, Signal Transducing
  • African Continental Ancestry Group
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease
  • European Continental Ancestry Group
  • Female
  • Genetic Predisposition to Disease
  • Genetic Variation
  • Genome-Wide Association Study
  • Genotype
  • Humans
  • Indians, North American
  • Male
  • Membrane Glycoproteins
  • Middle Aged
  • Phospholipase C gamma
  • Receptors, Immunologic

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