Transfer RNA is cleaved by activated bleomycin

R. S. Magliozzo, J. Peisach, M. R. Ciriolo

Research output: Contribution to journalArticlepeer-review

Abstract

Activated bleomycin is shown for the first time to cleave tRNA in a specific and dose-dependent manner. Adenine and uracil are released in the reaction. Bleomycin and Fe(III)-bleomycin bind to yeast tRNA(Phe) in analogy with the known behavior of the drug with B-DNA.

Original languageEnglish
Pages (from-to)428-432
Number of pages5
JournalMolecular Pharmacology
Volume35
Issue number4
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Pharmacology

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