Transferrin receptor gene and protein expression and localization in human IUGR and normal term placentas

C. Mandò, S. Tabano, P. Colapietro, P. Pileri, F. Colleoni, L. Avagliano, P. Doi, G. Bulfamante, M. Miozzo, I. Cetin

Research output: Contribution to journalArticle

Abstract

Iron (Fe) deficiency in pregnancy is associated to low birth weight and premature delivery while in adults it can result in increased blood pressure and cardiovascular disease. Cellular Fe uptake is mediated by the Transferrin Receptor 1 (TFRC), located in the trophoblast membranes. Here, we measured TFRC mRNA expression (Real Time PCR) and TFRC protein expression and localization (Western Blotting and immunohistochemistry) in IUGR compared to control placentas. A total of 50 IUGR and 56 control placentas were studied at the time of elective cesarean section. IUGR was defined by ultrasound in utero, and confirmed by birth weight

Original languageEnglish
Pages (from-to)44-50
Number of pages7
JournalPlacenta
Volume32
Issue number1
DOIs
Publication statusPublished - Jan 2011

Keywords

  • Growth
  • Intrauterine
  • Iron
  • Placenta
  • Restriction
  • Transferrin receptor 1

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine
  • Developmental Biology

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    Mandò, C., Tabano, S., Colapietro, P., Pileri, P., Colleoni, F., Avagliano, L., Doi, P., Bulfamante, G., Miozzo, M., & Cetin, I. (2011). Transferrin receptor gene and protein expression and localization in human IUGR and normal term placentas. Placenta, 32(1), 44-50. https://doi.org/10.1016/j.placenta.2010.10.009