Transforming growth factor β downregulates interleukin-1 (IL-1)-induced IL-6 production by human monocytes

Tiziana Musso, Igor Espinoza-Delgado, Kari Pulkki, Gabriele L. Gusella, Dan L. Longo, Luigi Varesio

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the effects of transforming growth factor β (TGFβ) on the induction by interleukin-1β (IL-1/β) of IL-6 in human monocytes. We found that IL-1β induced IL-6 messenger RNA expression in elutriated monocytes and IL-6 secretion in the supernatant. TGFβ did not induce IL-6. In contrast, TGFβ added to the culture inhibited, in a dose-dependent manner, the induction of IL-6 by IL-1 at the level of messenger RNA and bioactivity. These results show that IL-1β is able to stimulate IL-6 production by monocytes, TGFβ, by inhibiting this effect, may play an important role in regulating the IL-1-mediated components of the inflammatory response.

Original languageEnglish
Pages (from-to)2466-2469
Number of pages4
JournalBlood
Volume76
Issue number12
Publication statusPublished - Dec 15 1990

ASJC Scopus subject areas

  • Hematology

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