We investigated the effects of transforming growth factor β (TGFβ) on the induction by interleukin-1β (IL-1/β) of IL-6 in human monocytes. We found that IL-1β induced IL-6 messenger RNA expression in elutriated monocytes and IL-6 secretion in the supernatant. TGFβ did not induce IL-6. In contrast, TGFβ added to the culture inhibited, in a dose-dependent manner, the induction of IL-6 by IL-1 at the level of messenger RNA and bioactivity. These results show that IL-1β is able to stimulate IL-6 production by monocytes, TGFβ, by inhibiting this effect, may play an important role in regulating the IL-1-mediated components of the inflammatory response.
|Number of pages||4|
|Publication status||Published - Dec 15 1990|
ASJC Scopus subject areas