Transforming growth factor-β1 levels in hypertensive patients

Association with body mass index and leptin

Ettore Porreca, Concetta Di Febbo, Ester Vitacolonna, Giovanna Baccante, Augusto Di Castelnuovo, Antonio Angelini, Francesca Febo, Marcello Di Nisio, Franco Cuccurullo

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Background: Transforming growth factor-β1 (TGF-β1) has been demonstrated to be overexpressed in hypertension. Leptin, an adipocyte product, has been shown to play a role in obesity-related hypertension and in vitro studies demonstrated a biologic interaction between leptin and TGF-β1. Thus, we evaluate a possible in vivo association between TGF-β1, body mass index (BMI), and leptin circulating levels in hypertensive subjects. Methods: Blood samples for fasting leptin and TGF-β1, were evaluated in 29 overweight, 46 obese, and 29 nonobese hypertensive patients before and after a 12-week calorie-restricted diet. Monocyte cultures were used for in vitro experiments. Results: Transforming growth factor-β1 was significantly elevated in hypertensive obese patients (n = 46) as compared with TGF-β1 levels of hypertensive patients with normal BMI (n = 29) (8.9 ± 3 ng/mL v 4.4 ± 2; P <.001). The circulating levels of TGF-β1 were associated with BMI and leptin levels in an univariate analysis (r = 0.59, P <.0001; r = 0.62, P <.0001, respectively) and these associations were still present after stepwise multivariate analysis. Weight loss of 10% produced a parallel decrease in TGF-β1 (from 8.9 ± 3 ng/mL to 5.3 ± 2.8 ng/mL; P <.01) and leptin levels (from 30 ± 24 ng/mL to 17 ± 14; P <.05). In vitro experiments showed that leptin is able to induce a dose-dependent increase in TGF-β1 production and mRNA expression in human monocyte cultures. Conclusions: Our data indicate that TGF-β1 levels are positively associated with BMI and leptin levels in hypertensive patients and suggest that adipose tissue may be an important determinant of TGF-β1 levels possibly by a leptin-dependent pathway.

Original languageEnglish
Pages (from-to)759-765
Number of pages7
JournalAmerican Journal of Hypertension
Volume15
Issue number9
DOIs
Publication statusPublished - Sep 2002

Fingerprint

Transforming Growth Factors
Leptin
Body Mass Index
Monocytes
Hypertension
Adipocytes
Adipose Tissue
Weight Loss
Fasting
Multivariate Analysis
Obesity
Diet
Messenger RNA

Keywords

  • Hypertension
  • Leptin
  • Obesity
  • Transforming growth factor-β

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Transforming growth factor-β1 levels in hypertensive patients : Association with body mass index and leptin. / Porreca, Ettore; Di Febbo, Concetta; Vitacolonna, Ester; Baccante, Giovanna; Di Castelnuovo, Augusto; Angelini, Antonio; Febo, Francesca; Di Nisio, Marcello; Cuccurullo, Franco.

In: American Journal of Hypertension, Vol. 15, No. 9, 09.2002, p. 759-765.

Research output: Contribution to journalArticle

Porreca, E, Di Febbo, C, Vitacolonna, E, Baccante, G, Di Castelnuovo, A, Angelini, A, Febo, F, Di Nisio, M & Cuccurullo, F 2002, 'Transforming growth factor-β1 levels in hypertensive patients: Association with body mass index and leptin', American Journal of Hypertension, vol. 15, no. 9, pp. 759-765. https://doi.org/10.1016/S0895-7061(02)02978-3
Porreca, Ettore ; Di Febbo, Concetta ; Vitacolonna, Ester ; Baccante, Giovanna ; Di Castelnuovo, Augusto ; Angelini, Antonio ; Febo, Francesca ; Di Nisio, Marcello ; Cuccurullo, Franco. / Transforming growth factor-β1 levels in hypertensive patients : Association with body mass index and leptin. In: American Journal of Hypertension. 2002 ; Vol. 15, No. 9. pp. 759-765.
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AU - Vitacolonna, Ester

AU - Baccante, Giovanna

AU - Di Castelnuovo, Augusto

AU - Angelini, Antonio

AU - Febo, Francesca

AU - Di Nisio, Marcello

AU - Cuccurullo, Franco

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