Transforming growth factor beta 1 and vascular endothelial growth factor levels in the pathogenesis of periodontal disease

G. Matarese, Gaetano Isola, G. P. Anastasi, G. Cutroneo, G. Cordasco, A. Favaloro, G. Vita, G. Vermiglio, D. Milardi, V. L. Zizzari, S. Tetè, L. Perillo

Research output: Contribution to journalArticlepeer-review


Periodontal disease is characterized by inflammation and bone loss. The balance between inflammatory mediators and their counter-regulatory molecules may be fundamental for determining the outcome of immune pathology of periodontal disease. Cytokines play crucial roles in the maintenance of tissue homeostasis, a process which requires a delicate balance between anabolic and catabolic activities. In particular, two families of growth factors-such as transforming growth factor-β1 (TGF-β1) and vascular endothelial growth factor (VEGF) are thought to play important roles in modulating the proliferation and/or migration of structural cells involved in inflammation and regulation of immune responses. The aim of this work was to analyze gingival samples and periodontal tissue specimens collected from thirty-eight patients with chronic periodontal disease and from forty healthy individuals, in order to detect the expression and distribution of TGF-β1 and VEGF between the two groups. TGF-β1 and VEGF expression levels were detected using immunohistochemical analysis and computer-assisted morphometric analysis. The findings presented here suggest that biomarker such as TGF-β1 and VEGF have an important regulating role in the orchestration of the immune response, which in turn influence the outcome of disease establishment and evolution.

Original languageEnglish
Pages (from-to)479-488
Number of pages10
JournalEuropean Journal of Inflammation
Issue number2
Publication statusPublished - May 2013


  • Immunohistochemical analysis
  • Inflammation
  • Periodontal disease
  • TGF-beta 1
  • VEGF

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy


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