Abstract
Analysis of data available in 1985 on 3468 Italian and Greek patients registered in Cooleycare, an international cooperative programme of quality assessment of treatment delivery in thalassaemia, gave the following picture of treatment requirements and effects. The proportion of patients undergoing splenectomy has progressively decreased, and age at splenectomy has increased with time over the past 20 years. Age at first transfusion exceeds 4 years in a small but important group of patients, which indicates that a milder form of thalassaemia exists in this group. Children receiving modern treatment remain of near-normal stature until age 11 but later tend to be stunted. The mean blood requirement is 35% higher in non-splenectomised than in splenectomised patients. Differences in transfusion interval of 2 to 4 weeks have no measurable effect on blood requirement. Mean blood requirement rises gradually with mean haemoglobin concentration, possibly in a non-linear fashion. The prevalence of red cell alloimmunisation rises with delay in start on transfusion. Transfusion reactions were reported in 1% of transfusions (90% of which were leucocyte-depleted), from 17% of patients.
| Original language | English |
|---|---|
| Pages (from-to) | 277-280 |
| Number of pages | 4 |
| Journal | Lancet |
| Volume | 337 |
| Issue number | 8736 |
| DOIs | |
| Publication status | Published - Feb 2 1991 |
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ASJC Scopus subject areas
- Medicine(all)
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Transfusion requirements and effects in patients with thalassaemia major. / Rebulla, Paolo; Modell, Berndette.
In: Lancet, Vol. 337, No. 8736, 02.02.1991, p. 277-280.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Transfusion requirements and effects in patients with thalassaemia major
AU - Rebulla, Paolo
AU - Modell, Berndette
PY - 1991/2/2
Y1 - 1991/2/2
N2 - Analysis of data available in 1985 on 3468 Italian and Greek patients registered in Cooleycare, an international cooperative programme of quality assessment of treatment delivery in thalassaemia, gave the following picture of treatment requirements and effects. The proportion of patients undergoing splenectomy has progressively decreased, and age at splenectomy has increased with time over the past 20 years. Age at first transfusion exceeds 4 years in a small but important group of patients, which indicates that a milder form of thalassaemia exists in this group. Children receiving modern treatment remain of near-normal stature until age 11 but later tend to be stunted. The mean blood requirement is 35% higher in non-splenectomised than in splenectomised patients. Differences in transfusion interval of 2 to 4 weeks have no measurable effect on blood requirement. Mean blood requirement rises gradually with mean haemoglobin concentration, possibly in a non-linear fashion. The prevalence of red cell alloimmunisation rises with delay in start on transfusion. Transfusion reactions were reported in 1% of transfusions (90% of which were leucocyte-depleted), from 17% of patients.
AB - Analysis of data available in 1985 on 3468 Italian and Greek patients registered in Cooleycare, an international cooperative programme of quality assessment of treatment delivery in thalassaemia, gave the following picture of treatment requirements and effects. The proportion of patients undergoing splenectomy has progressively decreased, and age at splenectomy has increased with time over the past 20 years. Age at first transfusion exceeds 4 years in a small but important group of patients, which indicates that a milder form of thalassaemia exists in this group. Children receiving modern treatment remain of near-normal stature until age 11 but later tend to be stunted. The mean blood requirement is 35% higher in non-splenectomised than in splenectomised patients. Differences in transfusion interval of 2 to 4 weeks have no measurable effect on blood requirement. Mean blood requirement rises gradually with mean haemoglobin concentration, possibly in a non-linear fashion. The prevalence of red cell alloimmunisation rises with delay in start on transfusion. Transfusion reactions were reported in 1% of transfusions (90% of which were leucocyte-depleted), from 17% of patients.
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UR - http://www.scopus.com/inward/citedby.url?scp=0025970809&partnerID=8YFLogxK
U2 - 10.1016/0140-6736(91)90881-O
DO - 10.1016/0140-6736(91)90881-O
M3 - Article
C2 - 1671122
AN - SCOPUS:0025970809
VL - 337
SP - 277
EP - 280
JO - The Lancet
JF - The Lancet
SN - 0140-6736
IS - 8736
ER -