Transfusion-transmitted human parvovirus B19 infection in a thalassemic patient

A. Zanella, F. Rossi, C. Cesana, A. Foresti, F. Nador, A. S. Binda, G. Lunghi, M. D. Cappellini, C. M. Furione, G. Sirchia

Research output: Contribution to journalArticle

Abstract

Background: Human parvovirus (HPV) B19 infection has been shown to be transmissible by clotting factor concentrates, most often resulting in asymptomatic seroconversion. So far, no case of B19 transmission due to single-donor transfusion has been documented. Case Report: A case of transfusion-transmitted HPV B19 infection in a 22-year-old female thalassemia major patient is described. She presented with an aplastic crisis; this was followed 1 week later by transitory heart failure and acute tricuspid incompetence. The echocardiogram revealed a grade III tricuspid regurgitation and a floating vegetation on the atrial face of the tricuspid lateral leaflet. The tricuspid regurgitation and vegetation spontaneously disappeared within 15 days. Blood cultures for bacteria were repeatedly negative. IgM anti-HPV B19 seroconversion was documented in the acute phase. B19 DNA was detected by polymerase chain reaction and remained detectable up to 4 months after diagnosis. High-titer IgM anti-HPV and B19 DNA were also found in serum samples collected at the time of donation from one of the donors of the blood transfused before the onset of clinical symptoms. Conclusion: This case documents the transmission of HPV B19 by the transfusion of 1 red cell unit and the occurrence of possible transient cardiac involvement in this infectious complication.

Original languageEnglish
Pages (from-to)769-772
Number of pages4
JournalTransfusion
Volume35
Issue number9
Publication statusPublished - 1995

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Human Parvovirus B19
Parvoviridae Infections
Tricuspid Valve Insufficiency
Blood Coagulation Factors
beta-Thalassemia
DNA
Blood Donors
Heart Failure
Tissue Donors
Bacteria
Polymerase Chain Reaction
Serum

ASJC Scopus subject areas

  • Immunology
  • Hematology

Cite this

Zanella, A., Rossi, F., Cesana, C., Foresti, A., Nador, F., Binda, A. S., ... Sirchia, G. (1995). Transfusion-transmitted human parvovirus B19 infection in a thalassemic patient. Transfusion, 35(9), 769-772.

Transfusion-transmitted human parvovirus B19 infection in a thalassemic patient. / Zanella, A.; Rossi, F.; Cesana, C.; Foresti, A.; Nador, F.; Binda, A. S.; Lunghi, G.; Cappellini, M. D.; Furione, C. M.; Sirchia, G.

In: Transfusion, Vol. 35, No. 9, 1995, p. 769-772.

Research output: Contribution to journalArticle

Zanella, A, Rossi, F, Cesana, C, Foresti, A, Nador, F, Binda, AS, Lunghi, G, Cappellini, MD, Furione, CM & Sirchia, G 1995, 'Transfusion-transmitted human parvovirus B19 infection in a thalassemic patient', Transfusion, vol. 35, no. 9, pp. 769-772.
Zanella A, Rossi F, Cesana C, Foresti A, Nador F, Binda AS et al. Transfusion-transmitted human parvovirus B19 infection in a thalassemic patient. Transfusion. 1995;35(9):769-772.
Zanella, A. ; Rossi, F. ; Cesana, C. ; Foresti, A. ; Nador, F. ; Binda, A. S. ; Lunghi, G. ; Cappellini, M. D. ; Furione, C. M. ; Sirchia, G. / Transfusion-transmitted human parvovirus B19 infection in a thalassemic patient. In: Transfusion. 1995 ; Vol. 35, No. 9. pp. 769-772.
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