Transgenic mice overexpressing the wild-type form of the HMGA1 gene develop mixed growth hormone/prolactin cell pituitary adenomas and natural killer cell lymphomas

Monica Fedele, Francesca Pentimalli, Gustavo Baldassarre, Sabrina Battista, Andres J P Klein-Szanto, Lawrence Kenyon, Rosa Visone, Ivana De Martino, Andrea Ciarmiello, Claudio Arra, Giuseppe Viglietto, Carlo M. Croce, Alfredo Fusco

Research output: Contribution to journalArticlepeer-review

Abstract

Overexpression of HMGA1 proteins is a constant feature of human carcinomas. Moreover, rearrangements of this gene have been detected in several human benign tumors of mesenchymal origin. To define the role of these proteins in cell transformation in vivo, we have generated transgenic mice overexpressing ubiquitously the HMGA1 gene. These mice developed mixed growth hormone/prolactin cell pituitary adenomas and natural killer (NK)-T/NK cell lymphomas. The HMGA1-induced expression of IL-2 and IL-15 proteins and their receptors may account for the onset of these lymphomas. At odds with mice overexpressing a wild-type or a truncated HMGA2 protein, adrenal medullar hyperplasia and pancreatic islet cell hyperplasia frequently occurred and no increase in body size and weight was observed in HMGA1 mice. Taken together, these data indicate an oncogenic role of the HMGA1 gene also in vivo.

Original languageEnglish
Pages (from-to)3427-3435
Number of pages9
JournalOncogene
Volume24
Issue number21
DOIs
Publication statusPublished - May 12 2005

Keywords

  • High-mobility group proteins
  • IL-15
  • IL-2
  • Lymphomas
  • NK 1.1
  • Pituitary adenomas

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

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