Transglutaminase 2 expression is significantly increased in cyclosporine-induced gingival overgrowth sofia asioli

Alberto Righi, Pietro Cardone, Mario Aimetti, Francesca Maletta, Renato Coda, Stefano Carossa, Roberto Navone, Paola Cassoni

Research output: Contribution to journalArticlepeer-review


Cyclosporine A is a potent immunosuppressant used to prevent organ transplant rejection and treat various autoimmune diseases. However, cyclosporine A can also induce gingival overgrowth, which is characterized by increased extracellular matrix due to an altered balance between collagen synthesis and degradation. This study proposed to verify whether transglutaminase 2, an enzyme thought to be responsible for the assembly and remodelling of extracellular matrix, plays any role in the pathogenesis of cyclosporine Ainduced gingival overgrowth. Cyclosporine A-induced gingival overgrowths were collected from 21 liver transplant patients and casecontrolled with 20 non-hyperplastic gingival biopsies from healthy patients who had previous periodontal treatment. In both groups, the presence and tissue distribution of transglutaminase 2 were determined by immunohistochemistry and analyzed in comparison with the tissue morphology and expression of lymphocyterelated antigens (CD3 and CD20) and a vessel-related marker (CD34). Transglutaminase 2 expression showed a significant increase (2.6-fold) in the stromal component of cyclosporine A-treated patients compared with controls (p

Original languageEnglish
Pages (from-to)1399-1404
Number of pages6
JournalHistology and Histopathology
Issue number11
Publication statusPublished - Nov 2011


  • Cyclosporine
  • Gingiva
  • Overgrowth
  • Transglutaminase 2

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine


Dive into the research topics of 'Transglutaminase 2 expression is significantly increased in cyclosporine-induced gingival overgrowth sofia asioli'. Together they form a unique fingerprint.

Cite this