Transglutaminase Type 2 Regulates ER-Mitochondria Contact Sites by Interacting with GRP75

Manuela D'Eletto, Federica Rossin, Luca Occhigrossi, Maria Grazia Farrace, Danilo Faccenda, Radha Desai, Saverio Marchi, Giulia Refolo, Laura Falasca, Manuela Antonioli, Fabiola Ciccosanti, Gian Maria Fimia, Paolo Pinton, Michelangelo Campanella, Mauro Piacentini

Research output: Contribution to journalArticle

Abstract

TG2 is an enzyme that plays a key role in mitochondria homeostasis. D'eletto et al. found that TG2 interacts with GRP75, a protein localized in mitochondria-associated membranes (MAMs). TG2 regulates the number of ER-mitochondria contact sites and Ca2+ flux, suggesting a key regulatory role in MAMs.

Original languageEnglish
Pages (from-to)3573-3581.e4
JournalCell Reports
Volume25
Issue number13
DOIs
Publication statusPublished - Dec 26 2018

Keywords

  • ER-mitochondria contact sites
  • GRP75
  • MAMs
  • mitochondrial Ca
  • TG2

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    D'Eletto, M., Rossin, F., Occhigrossi, L., Farrace, M. G., Faccenda, D., Desai, R., Marchi, S., Refolo, G., Falasca, L., Antonioli, M., Ciccosanti, F., Fimia, G. M., Pinton, P., Campanella, M., & Piacentini, M. (2018). Transglutaminase Type 2 Regulates ER-Mitochondria Contact Sites by Interacting with GRP75. Cell Reports, 25(13), 3573-3581.e4. https://doi.org/10.1016/j.celrep.2018.11.094