TG2 is an enzyme that plays a key role in mitochondria homeostasis. D'eletto et al. found that TG2 interacts with GRP75, a protein localized in mitochondria-associated membranes (MAMs). TG2 regulates the number of ER-mitochondria contact sites and Ca2+ flux, suggesting a key regulatory role in MAMs.
- ER-mitochondria contact sites
- mitochondrial Ca
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)