Transglutaminases expression in human supraspinatus tendon ruptures and in mouse tendons

Francesco Oliva, Loredana Zocchi, Andrea Codispoti, Eleonora Candi, Monica Celi, Gerry Melino, Nicola Maffulli, Umberto Tarantino

Research output: Contribution to journalArticlepeer-review

Abstract

The ethiopathogenesis of rotator cuff disease remains poorly understood. Many studies advocate the importance of extra cellular matrix for the homeostasis of connective tissue. Transglutaminase enzymes family has been studied in the context of connective tissue formation and stabilisation. Here, we investigated transglutaminases expression pattern in biopsies of normal and injured supraspinatus tendons of human shoulders and in the Achilles tendons of transglutaminase 2 knock-out and wild-type mice. Our results show that different transglutaminase family members are differentially expressed in human and mouse tendons, and that transglutaminase 2 is down-regulated at mRNA and protein levels upon human supraspinatus tendon ruptures.

Original languageEnglish
Pages (from-to)887-891
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume379
Issue number4
DOIs
Publication statusPublished - Feb 20 2009

Keywords

  • Supraspinatus tendon
  • Tendons
  • TG2 knock-out mice
  • Transglutaminase

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

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