Il diabete neonatale, nelle sue forme transitorie e permanenti

Translated title of the contribution: Transient and permanent neonatal diabetes mellitus

Research output: Contribution to journalArticle

Abstract

Transient and permanent neonatal diabetes mellitus are rare conditions occuring in 1:400,000-500,000 newborns. Transient neonatal diabetes mellitus begins in the first few weeks of life and disappears in a few months with frequent later relapse as permanent type 2 diabetes in adolescence. It is mostly associated to genetic defects of the chromosome 6. Permanent neonatal diabetes requires treatment for life and until recently the genetic etiology was largely unknown. Now we know that the most common cause of permanent neonatal diabetes mellitus is associated with activating mutations in the genes, wich encode the subunits of the ATP-sensitive potassium channels. In this paper, we report the success of the sulphonylurea treatment in a case of permanent neonatal diabetes with activating mutations of KCNJ11.

Original languageItalian
Pages (from-to)169-172
Number of pages4
JournalMedico e Bambino
Volume26
Issue number3
Publication statusPublished - Mar 31 2007

Fingerprint

KATP Channels
Mutation
Chromosomes, Human, Pair 6
Type 2 Diabetes Mellitus
Diabetes Mellitus
Newborn Infant
Recurrence
Therapeutics
Genes
Permanent Neonatal Diabetes Mellitus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Il diabete neonatale, nelle sue forme transitorie e permanenti. / Faleschini, Elena.

In: Medico e Bambino, Vol. 26, No. 3, 31.03.2007, p. 169-172.

Research output: Contribution to journalArticle

@article{ee3683da1098466d8737f88eeecb2654,
title = "Il diabete neonatale, nelle sue forme transitorie e permanenti",
abstract = "Transient and permanent neonatal diabetes mellitus are rare conditions occuring in 1:400,000-500,000 newborns. Transient neonatal diabetes mellitus begins in the first few weeks of life and disappears in a few months with frequent later relapse as permanent type 2 diabetes in adolescence. It is mostly associated to genetic defects of the chromosome 6. Permanent neonatal diabetes requires treatment for life and until recently the genetic etiology was largely unknown. Now we know that the most common cause of permanent neonatal diabetes mellitus is associated with activating mutations in the genes, wich encode the subunits of the ATP-sensitive potassium channels. In this paper, we report the success of the sulphonylurea treatment in a case of permanent neonatal diabetes with activating mutations of KCNJ11.",
keywords = "Neonatal diabetes mellitus, Potassium channels, Sulphonylurea",
author = "Elena Faleschini",
year = "2007",
month = "3",
day = "31",
language = "Italian",
volume = "26",
pages = "169--172",
journal = "Medico e Bambino",
issn = "1591-3090",
publisher = "Medico e Bambino",
number = "3",

}

TY - JOUR

T1 - Il diabete neonatale, nelle sue forme transitorie e permanenti

AU - Faleschini, Elena

PY - 2007/3/31

Y1 - 2007/3/31

N2 - Transient and permanent neonatal diabetes mellitus are rare conditions occuring in 1:400,000-500,000 newborns. Transient neonatal diabetes mellitus begins in the first few weeks of life and disappears in a few months with frequent later relapse as permanent type 2 diabetes in adolescence. It is mostly associated to genetic defects of the chromosome 6. Permanent neonatal diabetes requires treatment for life and until recently the genetic etiology was largely unknown. Now we know that the most common cause of permanent neonatal diabetes mellitus is associated with activating mutations in the genes, wich encode the subunits of the ATP-sensitive potassium channels. In this paper, we report the success of the sulphonylurea treatment in a case of permanent neonatal diabetes with activating mutations of KCNJ11.

AB - Transient and permanent neonatal diabetes mellitus are rare conditions occuring in 1:400,000-500,000 newborns. Transient neonatal diabetes mellitus begins in the first few weeks of life and disappears in a few months with frequent later relapse as permanent type 2 diabetes in adolescence. It is mostly associated to genetic defects of the chromosome 6. Permanent neonatal diabetes requires treatment for life and until recently the genetic etiology was largely unknown. Now we know that the most common cause of permanent neonatal diabetes mellitus is associated with activating mutations in the genes, wich encode the subunits of the ATP-sensitive potassium channels. In this paper, we report the success of the sulphonylurea treatment in a case of permanent neonatal diabetes with activating mutations of KCNJ11.

KW - Neonatal diabetes mellitus

KW - Potassium channels

KW - Sulphonylurea

UR - http://www.scopus.com/inward/record.url?scp=34247532879&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247532879&partnerID=8YFLogxK

M3 - Articolo

VL - 26

SP - 169

EP - 172

JO - Medico e Bambino

JF - Medico e Bambino

SN - 1591-3090

IS - 3

ER -