Transient beneficial effect of GH replacement therapy and topical GH application on skin ulcers in a boy with prolidase deficiency

Virginia Monafo, Gian Luigi Marseglia, Mohamad Maghnie, Katherine M. Dyne, Giuseppe Cetta

Research output: Contribution to journalArticlepeer-review

Abstract

A diagnostic examination for short stature in a boy with chronic ulcers of the feet due to prolidase deficiency, a rare disorder associated with intractable ulcers of the skin, led to the diagnosis of growth hormone (GH) deficiency. Replacement treatment with r-hGH associated with the topical application of a GH-containing ointment when the boy was 13 years old resulted in complete but transitory heating of the ulcers, which can probably be attributed to the growth-promoting effects of GH on dermal connective tissue.

Original languageEnglish
Pages (from-to)227-230
Number of pages4
JournalPediatric Dermatology
Volume17
Issue number3
DOIs
Publication statusPublished - May 2000

ASJC Scopus subject areas

  • Dermatology
  • Pediatrics, Perinatology, and Child Health

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