Transient changes in brain tissue oxygen in response to modifications of cerebral perfusion pressure: An observational study

Danila K. Radolovich, Marek Czosnyka, Ivan Timofeev, Andrea Lavinio, Dong Joo Kim, Matthias Jaeger, Peter Hutchinson, Arun Gupta, John D. Pickard, Peter Smielewski

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: The relative merits of the mechanisms for the maintenance of brain tissue oxygenation (PbtO2) have been much debated. There is a wealth of studies regarding various factors that may determine the absolute value and changes in PbtO2. However, only a few of them analyzed fast (few minutes) and transient behavior of PbtO2 in response to variations (waves) of intracranial pressure (ICP) and cerebral perfusion pressure (CPP). Methods: This was a retrospective analysis and observational study. PbtO2, arterial blood pressure (ABP), and ICP waveforms were digitally monitored in 23 head-injured patients, admitted to the Neuroscience Critical Care Unit, who were sedated, paralyzed, and ventilated. Computer recordings were retrospectively reviewed. The dynamic changes in PbtO2 in response to transient changes in ABP and ICP were investigated. Results: Several patterns of response to short-lasting arterial hypotension and hypertension, intracranial hypertension, cerebral vasocycling, and cerebral hyperemia were observed and characterized. During the majority of the transient events, PbtO2 generally followed the direction of changes in CPP. Only during episodes of hyperemia, CPP and PbtO2 changed in the opposite direction. Changes in PbtO2 were delayed after dynamic changes in ABP, CPP, and ICP. The CPP-PbtO2 delay during changes provoked by variations in ABP was 35.0 s (range: maximum 827.0 s; minimum 0.0 s) compared with changes induced by variations in ICP of 0.0 s (range: maximum 265.0 s; minimum 0.0 s); the difference was significant at P <0.0001. Conclusions: PbtO2 is more than a number; it is rather a waveform following rapid changes in ICP and ABP. We show that PbtO2 generally tracks the direction of CPP irrespective of the state of cerebral autoregulation.

Original languageEnglish
Pages (from-to)165-173
Number of pages9
JournalAnesthesia and Analgesia
Volume110
Issue number1
DOIs
Publication statusPublished - Jan 2010

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Cerebrovascular Circulation
Intracranial Pressure
Observational Studies
Oxygen
Arterial Pressure
Brain
Hyperemia
Intracranial Hypertension
Critical Care
Neurosciences
Hypotension
Homeostasis
Retrospective Studies
Head
Maintenance
Hypertension

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Transient changes in brain tissue oxygen in response to modifications of cerebral perfusion pressure : An observational study. / Radolovich, Danila K.; Czosnyka, Marek; Timofeev, Ivan; Lavinio, Andrea; Kim, Dong Joo; Jaeger, Matthias; Hutchinson, Peter; Gupta, Arun; Pickard, John D.; Smielewski, Peter.

In: Anesthesia and Analgesia, Vol. 110, No. 1, 01.2010, p. 165-173.

Research output: Contribution to journalArticle

Radolovich, DK, Czosnyka, M, Timofeev, I, Lavinio, A, Kim, DJ, Jaeger, M, Hutchinson, P, Gupta, A, Pickard, JD & Smielewski, P 2010, 'Transient changes in brain tissue oxygen in response to modifications of cerebral perfusion pressure: An observational study', Anesthesia and Analgesia, vol. 110, no. 1, pp. 165-173. https://doi.org/10.1213/ANE.0b013e3181c0722f
Radolovich, Danila K. ; Czosnyka, Marek ; Timofeev, Ivan ; Lavinio, Andrea ; Kim, Dong Joo ; Jaeger, Matthias ; Hutchinson, Peter ; Gupta, Arun ; Pickard, John D. ; Smielewski, Peter. / Transient changes in brain tissue oxygen in response to modifications of cerebral perfusion pressure : An observational study. In: Anesthesia and Analgesia. 2010 ; Vol. 110, No. 1. pp. 165-173.
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