Transient effects of tumor location on the functional architecture at rest in glioblastoma patients

Three longitudinal case studies

Noora Tuovinen, Francesco de Pasquale, Massimo Caulo, Chiara Falletta Caravasso, Emilia Giudice, Roberto Miceli, Gianluca Ingrosso, Anne Laprie, Riccardo Santoni, Umberto Sabatini

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: The cognitive function of brain tumor patients is affected during the treatment. There is evidence that gliomas and surgery alter the functional brain connectivity but studies on the longitudinal effects are lacking. Methods: We acquired longitudinal (pre- and post-radiotherapy) resting-state functional magnetic resonance imaging on three selected glioblastoma patients. These cases were selected to study three models: a lesion involving a functional hub within a central system, a lesion involving a peripheral node within a central system and a lesion involving a peripheral node of a non-central system. Results: We found that, as expected, the tumor lesion affects connections in close vicinity, but when the lesion relates to a functional hub, these changes involve long-range connections leading to diverse connectivity profiles pre- and post-radiotherapy. In particular, a global but temporary improvement in the post-radiotherapy connectivity was obtained when treating a lesion close to a network hub, such as the posterior Cingulate Cortex. Conclusions: This suggests that this node re-establishes communication to nodes further away in the network. Eventually, these observed effects seem to be transient and on the long-term the tumor burden leads to an overall decline of connectivity following the course of the pathology. Furthermore, we obtained that the link between hubs, such as the Supplementary Motor Area and posterior Cingulate Cortex represents an important backbone by means of which within and across network communication is handled: the disruption of this connection seems to imply a strong decrease in the overall connectivity.

Original languageEnglish
Article number107
JournalRadiation Oncology
Volume11
Issue number1
DOIs
Publication statusPublished - Aug 17 2016

Fingerprint

Glioblastoma
Longitudinal Studies
Radiotherapy
Gyrus Cinguli
Neoplasms
Communication
Motor Cortex
Tumor Burden
Brain Neoplasms
Glioma
Cognition
Magnetic Resonance Imaging
Pathology
Brain
Therapeutics

Keywords

  • Brain tumor
  • Functional connectivity
  • Radiotherapy
  • Resting-state fMRI

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Tuovinen, N., de Pasquale, F., Caulo, M., Caravasso, C. F., Giudice, E., Miceli, R., ... Sabatini, U. (2016). Transient effects of tumor location on the functional architecture at rest in glioblastoma patients: Three longitudinal case studies. Radiation Oncology, 11(1), [107]. https://doi.org/10.1186/s13014-016-0683-x

Transient effects of tumor location on the functional architecture at rest in glioblastoma patients : Three longitudinal case studies. / Tuovinen, Noora; de Pasquale, Francesco; Caulo, Massimo; Caravasso, Chiara Falletta; Giudice, Emilia; Miceli, Roberto; Ingrosso, Gianluca; Laprie, Anne; Santoni, Riccardo; Sabatini, Umberto.

In: Radiation Oncology, Vol. 11, No. 1, 107, 17.08.2016.

Research output: Contribution to journalArticle

Tuovinen, N, de Pasquale, F, Caulo, M, Caravasso, CF, Giudice, E, Miceli, R, Ingrosso, G, Laprie, A, Santoni, R & Sabatini, U 2016, 'Transient effects of tumor location on the functional architecture at rest in glioblastoma patients: Three longitudinal case studies', Radiation Oncology, vol. 11, no. 1, 107. https://doi.org/10.1186/s13014-016-0683-x
Tuovinen, Noora ; de Pasquale, Francesco ; Caulo, Massimo ; Caravasso, Chiara Falletta ; Giudice, Emilia ; Miceli, Roberto ; Ingrosso, Gianluca ; Laprie, Anne ; Santoni, Riccardo ; Sabatini, Umberto. / Transient effects of tumor location on the functional architecture at rest in glioblastoma patients : Three longitudinal case studies. In: Radiation Oncology. 2016 ; Vol. 11, No. 1.
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