Transient elastography assessment of the liver stiffness dynamics during acute hepatitis B

Mauro Viganò, Sara Massironi, Pietro Lampertico, Massimo Iavarone, Silvia Paggi, Roberta Pozzi, Dario Conte, Massimo Colombo

Research output: Contribution to journalArticle

Abstract

Background and aims: The diagnostic accuracy of transient elastography (TE) for assessment of hepatic fibrosis is hampered by several factors, including acute parenchymal injury. Evaluation of liver stiffness (LS) using TE during acute hepatitis B may help to assess chronic hepatitis B patients with flares. Patients and methods: Twelve patients consecutively referred for acute hepatitis B, underwent sequential examinations with TE and laboratory examinations for 24 weeks. Results: On admission, aminotransferase ranged from 487 to 6067 IU/l (median=2590 IU/l) and LS ranged from 7.1 to 57kPa (median=15.6kPa) with nine (75%) patients showing LS greater than 11.9kPa, that is, the predictive cutoff for cirrhosis. LS levels correlated significantly with bilirubin, only (r≤0.58, P

Original languageEnglish
Pages (from-to)180-184
Number of pages5
JournalEuropean Journal of Gastroenterology and Hepatology
Volume22
Issue number2
DOIs
Publication statusPublished - Feb 2010

Keywords

  • Acute hepatitis B
  • FibroScan
  • Liver stiffness
  • Transient elastography

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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