Transient elastography is a useful noninvasive tool for the evaluation of fibrosis in paediatric chronic liver disease

Emer Fitzpatrick, Alberto Quaglia, Sunitha Vimalesvaran, Maria Sole Basso, Anil Dhawan

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Outcome of liver disease in children is mainly determined by severity and progression of liver fibrosis. Liver biopsy is the accepted standard for evaluating fibrosis but is limited by the need for sedation in children, sampling error, and risks including bleeding. The aim of the present study was to compare tools for noninvasive assessment of liver fibrosis in a paediatric cohort. METHODS: Children undergoing liver biopsy for chronic liver disease were recruited and underwent transient elastography (TE). Liver biopsies were scored by a hepatohistopathologist from F0 (no fibrosis) to F4 (cirrhosis). TE was compared with biopsy score. RESULTS: During the study period, 104 children (62 boys) were enrolled (median age 13.6 years). Diagnosis was autoimmune liver disease in 27; nonalcoholic fatty liver disease in 37; posttransplant in 16; hepatitis B/C in 8; Wilson disease in 5; and the remainder, miscellaneous. TE was successful in all but 7 patients and was a good discriminator of significant fibrosis (≥F2) (P

Original languageEnglish
Pages (from-to)72-76
Number of pages5
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume56
Issue number1
DOIs
Publication statusPublished - Jan 2013

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Keywords

  • fibrosis
  • noninvasive marker
  • transient elastography

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health

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