Abstract
BACKGROUND: Outcome of liver disease in children is mainly determined by severity and progression of liver fibrosis. Liver biopsy is the accepted standard for evaluating fibrosis but is limited by the need for sedation in children, sampling error, and risks including bleeding. The aim of the present study was to compare tools for noninvasive assessment of liver fibrosis in a paediatric cohort. METHODS: Children undergoing liver biopsy for chronic liver disease were recruited and underwent transient elastography (TE). Liver biopsies were scored by a hepatohistopathologist from F0 (no fibrosis) to F4 (cirrhosis). TE was compared with biopsy score. RESULTS: During the study period, 104 children (62 boys) were enrolled (median age 13.6 years). Diagnosis was autoimmune liver disease in 27; nonalcoholic fatty liver disease in 37; posttransplant in 16; hepatitis B/C in 8; Wilson disease in 5; and the remainder, miscellaneous. TE was successful in all but 7 patients and was a good discriminator of significant fibrosis (≥F2) (P
| Original language | English |
|---|---|
| Pages (from-to) | 72-76 |
| Number of pages | 5 |
| Journal | Journal of Pediatric Gastroenterology and Nutrition |
| Volume | 56 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2013 |
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Keywords
- fibrosis
- noninvasive marker
- transient elastography
ASJC Scopus subject areas
- Gastroenterology
- Pediatrics, Perinatology, and Child Health
Cite this
Transient elastography is a useful noninvasive tool for the evaluation of fibrosis in paediatric chronic liver disease. / Fitzpatrick, Emer; Quaglia, Alberto; Vimalesvaran, Sunitha; Basso, Maria Sole; Dhawan, Anil.
In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 56, No. 1, 01.2013, p. 72-76.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Transient elastography is a useful noninvasive tool for the evaluation of fibrosis in paediatric chronic liver disease
AU - Fitzpatrick, Emer
AU - Quaglia, Alberto
AU - Vimalesvaran, Sunitha
AU - Basso, Maria Sole
AU - Dhawan, Anil
PY - 2013/1
Y1 - 2013/1
N2 - BACKGROUND: Outcome of liver disease in children is mainly determined by severity and progression of liver fibrosis. Liver biopsy is the accepted standard for evaluating fibrosis but is limited by the need for sedation in children, sampling error, and risks including bleeding. The aim of the present study was to compare tools for noninvasive assessment of liver fibrosis in a paediatric cohort. METHODS: Children undergoing liver biopsy for chronic liver disease were recruited and underwent transient elastography (TE). Liver biopsies were scored by a hepatohistopathologist from F0 (no fibrosis) to F4 (cirrhosis). TE was compared with biopsy score. RESULTS: During the study period, 104 children (62 boys) were enrolled (median age 13.6 years). Diagnosis was autoimmune liver disease in 27; nonalcoholic fatty liver disease in 37; posttransplant in 16; hepatitis B/C in 8; Wilson disease in 5; and the remainder, miscellaneous. TE was successful in all but 7 patients and was a good discriminator of significant fibrosis (≥F2) (P
AB - BACKGROUND: Outcome of liver disease in children is mainly determined by severity and progression of liver fibrosis. Liver biopsy is the accepted standard for evaluating fibrosis but is limited by the need for sedation in children, sampling error, and risks including bleeding. The aim of the present study was to compare tools for noninvasive assessment of liver fibrosis in a paediatric cohort. METHODS: Children undergoing liver biopsy for chronic liver disease were recruited and underwent transient elastography (TE). Liver biopsies were scored by a hepatohistopathologist from F0 (no fibrosis) to F4 (cirrhosis). TE was compared with biopsy score. RESULTS: During the study period, 104 children (62 boys) were enrolled (median age 13.6 years). Diagnosis was autoimmune liver disease in 27; nonalcoholic fatty liver disease in 37; posttransplant in 16; hepatitis B/C in 8; Wilson disease in 5; and the remainder, miscellaneous. TE was successful in all but 7 patients and was a good discriminator of significant fibrosis (≥F2) (P
KW - fibrosis
KW - noninvasive marker
KW - transient elastography
UR - http://www.scopus.com/inward/record.url?scp=84872322497&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872322497&partnerID=8YFLogxK
U2 - 10.1097/MPG.0b013e31826f2760
DO - 10.1097/MPG.0b013e31826f2760
M3 - Article
C2 - 22922372
AN - SCOPUS:84872322497
VL - 56
SP - 72
EP - 76
JO - Journal of Pediatric Gastroenterology and Nutrition
JF - Journal of Pediatric Gastroenterology and Nutrition
SN - 0277-2116
IS - 1
ER -