TY - JOUR
T1 - Transient epileptic amnesia mistaken for mild cognitive impairment? A high-density EEG study
AU - Del Felice, Alessandra
AU - Broggio, Elisabetta
AU - Valbusa, Valeria
AU - Gambina, Giuseppe
AU - Arcaro, Chiara
AU - Manganotti, Paolo
PY - 2014
Y1 - 2014
N2 - Mild cognitive impairment (MCI) converts to Alzheimer's disease within a few years of diagnosis in up to 80% of patients. The identification among such a population of a rare form of epilepsy (transient epileptic amnesia [TEA]), characterized by mixed anterograde and retrograde amnesia with apparent preservation of other cognitive functions, excessively rapid decay of newly acquired memories, and loss of memories for salient personal events of the remote past, strongly affects prognosis and medical treatment. Our aim was to define the clinical utility of routine high-density electroencephalography (EEG) in patients with MCI for the detection of epilepsy, especially TEA. Using high-density EEG (256 channels), we were able to single out 3 cases of TEA previously misdiagnosed as MCI in this cohort of 76 consecutive patients with MCI diagnosed at our center. Antiepileptic treatment effectively stopped the acute episodes of memory loss. To our knowledge, this is the first report of an incidence of 4% of TEA recorded in such a cohort.
AB - Mild cognitive impairment (MCI) converts to Alzheimer's disease within a few years of diagnosis in up to 80% of patients. The identification among such a population of a rare form of epilepsy (transient epileptic amnesia [TEA]), characterized by mixed anterograde and retrograde amnesia with apparent preservation of other cognitive functions, excessively rapid decay of newly acquired memories, and loss of memories for salient personal events of the remote past, strongly affects prognosis and medical treatment. Our aim was to define the clinical utility of routine high-density electroencephalography (EEG) in patients with MCI for the detection of epilepsy, especially TEA. Using high-density EEG (256 channels), we were able to single out 3 cases of TEA previously misdiagnosed as MCI in this cohort of 76 consecutive patients with MCI diagnosed at our center. Antiepileptic treatment effectively stopped the acute episodes of memory loss. To our knowledge, this is the first report of an incidence of 4% of TEA recorded in such a cohort.
KW - 256-channel EEG
KW - Incidence
KW - Mild cognitive deterioration
KW - Transient epileptic amnesia
UR - http://www.scopus.com/inward/record.url?scp=84901191667&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84901191667&partnerID=8YFLogxK
U2 - 10.1016/j.yebeh.2014.04.014
DO - 10.1016/j.yebeh.2014.04.014
M3 - Article
C2 - 24857807
AN - SCOPUS:84901191667
VL - 36
SP - 41
EP - 46
JO - Epilepsy and Behavior
JF - Epilepsy and Behavior
SN - 1525-5050
ER -