Transient global ventricular dysfunction in an adolescent affected by pancreatic adenocarcinoma

Maria Debora De Pasquale, Angela Mastronuzzi, Luigi De Sio, Annalisa Serra, Chiara Grimaldi, Marcello Chinali, Ugo Giordano

Research output: Contribution to journalArticlepeer-review


Background: Takotsubo cardiomyopathy (TC) is characterized by a transient decrease in ejection fraction and a reversible left ventricular dysfunction. The pathophysiology of TC is not completely understood. Heterogeneous and multifactorial mechanisms are involved: drugs, emotional and physical stress, genetic and hormonal factors. Case presentation: A 17 year-old male with metastatic pancreatic adenocarcinoma, under chemotherapy containing 5-fluorouracil, presented severe left ventricular dysfunction requiring mechanical ventilation and inotropes administration. He completely recovered in 2 weeks. Conclusion: To our knowledge this is the first report of transient form of ventricular dysfunction, mimicking TC, in an adolescent. We believe that children and adolescents receiving 5-fluorouracil should be closely monitored and referred for investigation if they develop cardiac symptoms.

Original languageEnglish
Article number99
JournalBMC Pediatrics
Issue number1
Publication statusPublished - Jul 19 2016


  • Pancreatic carcinoma
  • Pediatrics
  • Reversible left ventricular dysfunction
  • Takotsubo cardiomyopathy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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