Transient global ventricular dysfunction in an adolescent affected by pancreatic adenocarcinoma

Maria Debora De Pasquale, Angela Mastronuzzi, Luigi De Sio, Annalisa Serra, Chiara Grimaldi, Marcello Chinali, Ugo Giordano

Research output: Contribution to journalArticle

Abstract

Background: Takotsubo cardiomyopathy (TC) is characterized by a transient decrease in ejection fraction and a reversible left ventricular dysfunction. The pathophysiology of TC is not completely understood. Heterogeneous and multifactorial mechanisms are involved: drugs, emotional and physical stress, genetic and hormonal factors. Case presentation: A 17 year-old male with metastatic pancreatic adenocarcinoma, under chemotherapy containing 5-fluorouracil, presented severe left ventricular dysfunction requiring mechanical ventilation and inotropes administration. He completely recovered in 2 weeks. Conclusion: To our knowledge this is the first report of transient form of ventricular dysfunction, mimicking TC, in an adolescent. We believe that children and adolescents receiving 5-fluorouracil should be closely monitored and referred for investigation if they develop cardiac symptoms.

Original languageEnglish
Article number99
JournalBMC Pediatrics
Volume16
Issue number1
DOIs
Publication statusPublished - Jul 19 2016

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Takotsubo Cardiomyopathy
Ventricular Dysfunction
Adenocarcinoma
Left Ventricular Dysfunction
Fluorouracil
A 17
Psychological Stress
Artificial Respiration
Drug Therapy
Pharmaceutical Preparations

Keywords

  • Pancreatic carcinoma
  • Pediatrics
  • Reversible left ventricular dysfunction
  • Takotsubo cardiomyopathy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Transient global ventricular dysfunction in an adolescent affected by pancreatic adenocarcinoma. / De Pasquale, Maria Debora; Mastronuzzi, Angela; De Sio, Luigi; Serra, Annalisa; Grimaldi, Chiara; Chinali, Marcello; Giordano, Ugo.

In: BMC Pediatrics, Vol. 16, No. 1, 99, 19.07.2016.

Research output: Contribution to journalArticle

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AU - Chinali, Marcello

AU - Giordano, Ugo

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