TY - JOUR
T1 - Transient global ventricular dysfunction in an adolescent affected by pancreatic adenocarcinoma
AU - De Pasquale, Maria Debora
AU - Mastronuzzi, Angela
AU - De Sio, Luigi
AU - Serra, Annalisa
AU - Grimaldi, Chiara
AU - Chinali, Marcello
AU - Giordano, Ugo
PY - 2016/7/19
Y1 - 2016/7/19
N2 - Background: Takotsubo cardiomyopathy (TC) is characterized by a transient decrease in ejection fraction and a reversible left ventricular dysfunction. The pathophysiology of TC is not completely understood. Heterogeneous and multifactorial mechanisms are involved: drugs, emotional and physical stress, genetic and hormonal factors. Case presentation: A 17 year-old male with metastatic pancreatic adenocarcinoma, under chemotherapy containing 5-fluorouracil, presented severe left ventricular dysfunction requiring mechanical ventilation and inotropes administration. He completely recovered in 2 weeks. Conclusion: To our knowledge this is the first report of transient form of ventricular dysfunction, mimicking TC, in an adolescent. We believe that children and adolescents receiving 5-fluorouracil should be closely monitored and referred for investigation if they develop cardiac symptoms.
AB - Background: Takotsubo cardiomyopathy (TC) is characterized by a transient decrease in ejection fraction and a reversible left ventricular dysfunction. The pathophysiology of TC is not completely understood. Heterogeneous and multifactorial mechanisms are involved: drugs, emotional and physical stress, genetic and hormonal factors. Case presentation: A 17 year-old male with metastatic pancreatic adenocarcinoma, under chemotherapy containing 5-fluorouracil, presented severe left ventricular dysfunction requiring mechanical ventilation and inotropes administration. He completely recovered in 2 weeks. Conclusion: To our knowledge this is the first report of transient form of ventricular dysfunction, mimicking TC, in an adolescent. We believe that children and adolescents receiving 5-fluorouracil should be closely monitored and referred for investigation if they develop cardiac symptoms.
KW - Pancreatic carcinoma
KW - Pediatrics
KW - Reversible left ventricular dysfunction
KW - Takotsubo cardiomyopathy
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U2 - 10.1186/s12887-016-0628-4
DO - 10.1186/s12887-016-0628-4
M3 - Article
AN - SCOPUS:84984619689
VL - 16
JO - BMC Pediatrics
JF - BMC Pediatrics
SN - 1471-2431
IS - 1
M1 - 99
ER -