Transient hypohidrosis induced by topiramate

Piero De Carolis, Fabiola Magnifico, Giulia Pierangeli, Rita Rinaldi, Massimo Galeotti, Sabina Cevoli, Pietro Cortelli

Research output: Contribution to journalArticlepeer-review


Purpose: Hypohidrosis during topiramate (TPM) treatment was recently reported in children. We describe an adult epilepsy patient who developed inability to sweat as well as heat intolerance while undergoing treatment with TPM. Methods: To detect the site of the sweat block, patient underwent examination of sweat gland function, cardiovascular autonomic test, and body temperature rhythm determination. Results: During TPM treatment, cardiovascular autonomic function and circadian rhythm of body core temperature were normal, whereas thermoregulatory sweat test (TST) showed anhydrosis. This adverse drug effect was quickly resolved after drug discontinuation. Conclusions: Because of normal cardiovascular autonomic function and central and peripheral thermoregulatory mechanisms, we hypothesize that hypohidrosis during TPM treatment could be due to a carbonic anhydrases (CA) block at the level of sweat gland.

Original languageEnglish
Pages (from-to)974-976
Number of pages3
Issue number7
Publication statusPublished - Jul 1 2003


  • Adverse effects
  • Epilepsy
  • Hypohidrosis
  • Neurophysiological studies
  • Topiramate

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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