TY - JOUR
T1 - Transient intermittent lymphocyte activation is responsible for the instability of angina
AU - Neri Serneri, Gian Gastone
AU - Abbate, Rosanna
AU - Gori, Anna Maria
AU - Attanasio, Monica
AU - Martini, Francesca
AU - Giusti, Betti
AU - Dabizzi, Piero
AU - Poggesi, Loredana
AU - Modesti, Pietro Amedeo
AU - Trotta, Francesco
AU - Rostagno, Carlo
AU - Boddi, Maria
AU - Gensini, Gian Franco
PY - 1992/9
Y1 - 1992/9
N2 - Background. Blood clotting activation is an important component of the inflammatory response; the outbursts of unstable angina are usually associated with increased thrombin formation and coronary mural thrombosis. Methods and Results. To investigate 1) whether monocyte activation is responsible for the enhanced thrombin formation during bursts of unstable angina and 2) what mechanism(s) might be responsible for monocyte activation, we studied patients with unstable angina (n=31), stable effort angina (n=23), left endoventricular thrombosis (n=8), and control subjects (n=44), measuring plasma fibrinopeptide A (FPA) levels and the capacity of monocytes to express procoagulant activity (PCA) and of lymphocytes to modulate this expression. Patients with unstable angina and patients with endoventricular thrombosis had significantly (p5 monocytes, median and range; 120, 1.1-463.2 versus 10.8, 0.8-39.1 in control subjects; p
AB - Background. Blood clotting activation is an important component of the inflammatory response; the outbursts of unstable angina are usually associated with increased thrombin formation and coronary mural thrombosis. Methods and Results. To investigate 1) whether monocyte activation is responsible for the enhanced thrombin formation during bursts of unstable angina and 2) what mechanism(s) might be responsible for monocyte activation, we studied patients with unstable angina (n=31), stable effort angina (n=23), left endoventricular thrombosis (n=8), and control subjects (n=44), measuring plasma fibrinopeptide A (FPA) levels and the capacity of monocytes to express procoagulant activity (PCA) and of lymphocytes to modulate this expression. Patients with unstable angina and patients with endoventricular thrombosis had significantly (p5 monocytes, median and range; 120, 1.1-463.2 versus 10.8, 0.8-39.1 in control subjects; p
KW - Angina, effort
KW - Angina, unstable
KW - Monocytes
KW - Tissue factor
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M3 - Article
C2 - 1516190
AN - SCOPUS:0026795112
VL - 86
SP - 790
EP - 797
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 3
ER -