Transient ischemic dilation in patients with diabetes mellitus prognostic value and effect on clinical outcome after coronary revascularization

Mario Petretta, Wanda Acampa, Stefania Daniele, Maria Piera Petretta, Monica Plaitano, Alberto Cuocolo

Research output: Contribution to journalArticlepeer-review

Abstract

Background-We prospectively evaluated the incremental prognostic value of transient ischemic dilation (TID) in patients with type 2 diabetes mellitus during long-term follow-up and estimated cardiac death and nonfatal myocardial infarction (MI) using traditional approaches of prognostication to more recent methods. Methods and Results-A total of 672 consecutive diabetic patients with available rest and stress gated myocardial perfusion single-photon emission computed tomographic data were enrolled. Stepwise Cox regression analysis was used to estimate cardiac death or nonfatal MI. Risk reclassification was calculated, and an exploratory analysis was performed to evaluate the effect of coronary revascularization on event-free survival. Adding TID to a multivariable model, including age, history of MI, stress type, poststress left ventricular ejection fraction, and stress-induced myocardial ischemia, improved discrimination of cardiac death or nonfatal MI (C statistic, 0.74-0.82; P=0.01; adjusted hazard ratio, 3.6; P

Original languageEnglish
Pages (from-to)908-915
Number of pages8
JournalCirculation: Cardiovascular Imaging
Volume6
Issue number6
DOIs
Publication statusPublished - Nov 2013

Keywords

  • Diabetes mellitus
  • Myocardial perfusion imaging
  • Prognosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Transient ischemic dilation in patients with diabetes mellitus prognostic value and effect on clinical outcome after coronary revascularization'. Together they form a unique fingerprint.

Cite this