Transient left ventricular apical ballooning at the onset of multiple system atrophy

Sara Ripa, Cesa Scaglione, Luigi Cesare Rusconi

Research output: Contribution to journalArticle


A 64-year-old woman was admitted to our hospital for persistent lipothymia and exertional dyspnoea and was treated for worsening asthma. During hospital stay, she manifested typical chest pain, with electrocardiographic and echocardiographic abnormalities suggesting acute myocardial infarction. Coronary angiography demonstrated normal coronary arteries and left ventriculography revealed apical akinesis. Creatine kinase levels showed a slight increase in spite of the severe ventricular abnormalities. The electrocardiographic and echocardiographic evolution, along with the favourable outcome, led us to diagnose tako-tsubo cardiomyopathy. Afterwards, severe autonomic dysfunction with multiple system atrophy was diagnosed.Impaired multivessel coronary microcirculation is thought to be one causative mechanism of tako-tsubo-like left ventricular dysfunction, and catecholamines are likely to play a role. In our case, sympathetic neurocirculatory failure was indicative of altered sympathoneural activity. We suggest that the prescribed therapy contributed to the development of this syndrome; in particular dopamine for hypotension and corticosteroids for suspected asthma stimulated heart sympathetic terminals.

Original languageEnglish
Pages (from-to)631-636
Number of pages6
JournalJournal of Cardiovascular Medicine
Issue number8
Publication statusPublished - Aug 2006


  • Multiple system atrophy
  • Transient left ventricular apical ballooning

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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